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Review ArticleMechanisms of Disease

Eosinophilia

List of authors.
  • Marc E. Rothenberg, M.D., Ph.D.

A marked accumulation of eosinophils occurs in several important disorders, such as allergic diseases, parasitic infections, and cancer.1 The level of eosinophils in the body is normally tightly regulated. In normal subjects, eosinophils account for only a small minority of peripheral-blood leukocytes, and their presence in tissues is primarily limited to the gastrointestinal mucosa.2 In certain disease states, however, eosinophils can selectively accumulate in the peripheral blood or any tissue in the body. Any perturbation that results in eosinophilia, defined here as an abnormal accumulation of eosinophils in blood or tissue, can have profound clinical effects. Eosinophilia may be harmful, . . .

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Funding and Disclosures

I am indebted to Drs. R. Wilmott, F. Finkelman, R. Hirsch, A. Assa'ad, and D. Glass for critical review of the manuscript; to Drs. E. Gelfand, P. Weller, K.F. Austen, P. Leder, and J. Rothenberg for helpful discussions; and to Dr. D.G. Nathan for the encouragement to write this article.

Author Affiliations

From the Department of Pediatrics, Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, where reprint requests should be addressed to Dr. Rothenberg.

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