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Review ArticleDrug Therapy

Nicotine Medications for Smoking Cessation

List of authors.
  • Jack E. Henningfield, Ph.D.

Cigarettes are among the most addicting products known, and the vast majority of people who quit smoking relapse within days.1,2 In the United States, less than 10 percent of the nearly 20 million people who quit smoking for a day remain abstinent one year later.3 Thus, only 2 to 3 percent of smokers become nonsmokers each year.3 Medications that contain nicotine enable health care providers to increase markedly the ability of their patients to achieve and sustain tobacco abstinence. This review summarizes the scientific rationale for nicotine medications, to help clinicians optimize their use.Pathophysiology of Nicotine AddictionClinical . . .

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Funding and Disclosures

I am indebted to Mr. A. Radzius for assistance in preparing the tables and figures, to Ms. M. Hoffman and Ms. P. Thomas for editorial assistance and assistance in the preparation of the manuscript, and to Drs. S. Heishman, D. Jasinski, R. Keenan, R. Nelson, W. Pickworth, and L. Schuh for their critical commentary on the manuscript.

Author Affiliations

From the Clinical Pharmacology Branch, Addiction Research Center, Intramural Research Program, National Institute on Drug Abuse, and the Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine — both in Baltimore.

Address reprint requests to Dr. Henningfield at the NIDA Addiction Research Center, P.O. Box 5180, Baltimore, MD 21224.

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