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CorrespondenceArchive

Error in Prenatal Diagnosis by DNA Analysis

To the Editor: In May 1983 we presented our five years' experience with DNA analysis for prenatal diagnosis of hemoglobinopathies.1 At that time we reported on 95 cases, 78 of which had been subsequently studied. In all these 78 cases the prenatal diagnosis was proved to be correct. Since that time the applicability of prenatal testing for sickle-cell anemia by DNA studies has been improved because of the development of a direct detection analysis using the endonuclease MstII2,3 or its isoschizomer, CvnI. Our total experience is now with just over 300 pregnancies studied for a hemoglobinopathy risk. Follow-up . . .

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