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Medical ProgressArchive

Bone-Marrow Transplantation — (First of Two Parts)

List of authors.
  • E. Donnall Thomas, M.D.,
  • Rainer Storb, M.D.,
  • Reginald A. Clift, F.I.M.L.T.,
  • Alexander Fefer, M.D.,
  • F. Leonard Johnson, M.B., B.S.,
  • Paul E. Neiman, M.D.,
  • Kenneth G. Lerner, M.D.,
  • Harold Glucksberg, M.D.,
  • and C. Dean Buckner, M.D.

THE modern era of bone-marrow transplantation was ushered in by the experiments of Jacobsen, Lorenz and their colleagues, who showed that mice could be protected against otherwise lethal irradiation by shielding of the spleen1 or by intravenous infusion of marrow.2 At first it was thought that this protective effect was due to a humoral factor.3 By 1956, however, several laboratories, using a variety of blood genetic markers, demonstrated that the protective effect against lethal irradiation was due to the colonization of the recipient marrow by donor cells.4 5 6 7An article on clinical marrow transplantation that appeared in . . .

Funding and Disclosures

Supported by grants (CA 10895, CA 10777, CA 10167 and CA 05231) from the National Cancer Institute, AI 09419 and Contract AI-32511 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and CP-3-3236 within the Virus Cancer Program of the National Cancer Institute, and a grant (CI-52) from the American Cancer Society (Dr. Thomas is the recipient of a research career award [AI 02425] from the National Institute of Allergy and Infectious Diseases, Drs. Fefer and Neiman are scholars of the Leukemia Society of America, and Dr. Glucksberg is a fellow of the American Cancer Society).

Author Affiliations

From the Department of Medicine, Division of Oncology, University of Washington School of Medicine, the Providence Medical Center, and the Fred Hutchinson Cancer Research Center (address reprint requests to Dr. Thomas at the Providence Medical Center, 500–17th Ave., Seattle, WA 98122).

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