Thrombogenesis

I SHOULD like to develop a concept of the normal hemostatic mechanism and of the pathogenesis of thrombosis consistent with the pathways of coagulation of blood as they are now understood. When possible I shall draw on in vivo experiments to buttress my remarks. The understanding of blood coagulation, however, is still imperfect, and knowledge of it derives primarily from tests performed outside the body.Pathologists recognize 3 types of thrombus, each of which may have a different pathophysiology. The first is the red thrombus, which is composed primarily of red cells and fibrin. Its morphology closely resembles that of . . .