Mycobacterium tuberculosis remains a major global health threat. In this report, the M72/AS01_E vaccine provided approximately 50% protection against progression to active tuberculosis disease in adults.

Intravenous valproate, levetiracetam, and fosphenytoin stopped status epilepticus that was resistant to initial treatment with lorazepam in approximately half the patients and did not differ significantly in effectiveness. Hypotension was numerically — but not significantly — more frequent with fosphenytoin.

In this randomized trial, women with extremely dense breast tissue were invited to undergo MRI screening or received only mammography during a 2-year screening period. There was a 50% lower rate of interval cancers among the women invited for MRI screening. Among those who underwent MRI-directed biopsies, 26% had breast cancer.

In this letter, public health authorities in Australia report on the recent emergence and dissemination, among men who have sex with men, of shigella that is resistant to all commonly used oral agents.

Approximately 0.6% of the U.S. population identifies as transgender. Depending on patient preference, treatment may involve hormone therapy (testosterone in transgender men, estrogens and androgen-lowering agents in transgender women), surgery customized to patient goals, and fertility preservation.

Many more patients are labeled as penicillin-allergic than actually are allergic. The label should be analyzed with skin testing and test exposure. Patients with true penicillin allergy can be desensitized with a slow-escalation protocol under physician observation.

A 57-year-old woman presented to the ED after a traumatic motorcycle accident. Bleeding from the pelvis and thigh resulted in hemorrhagic shock. Emergency management decisions were made, and therapeutic procedures were performed.