This open-label, 40-week, phase 3 trial assessed the efficacy and safety of tirzepatide, a weekly dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist under development for type 2 diabetes. Tirzepatide was noninferior and superior to semaglutide with respect to the mean change in the glycated hemoglobin level from baseline to 40 weeks.

In this randomized, controlled trial involving men who have sex with men being treated in five Australian sexual health clinics, 7-day doxycycline therapy was found to be superior to single-dose azithromycin for the treatment of rectal chlamydia infection.

A study involving 38 patients who initially had a response to adagrasib or who had a long period of stable disease in response to the drug but then had progression yielded diverse mechanisms of acquired resistance in 45% of them. Unlike resistance to the tyrosine kinase inhibitors, the cancer cell uses many mechanisms to overcome the inhibition of KRAS.

Six patients previously infected with the original SARS-CoV-2 virus received the BNT162b2 vaccine. Before vaccination, they had neutralizing activity against the B.1.1.7 and P.1 variants but not the B.1.351 variant. After one dose, neutralizing activity against all variants increased substantially.

Guiding the beta-emitting isotope lutetium-177 to prostate cancer lesions with the prostate-specific membrane antigen–targeted radioligand ¹⁷⁷Lu-PSMA-617 plus using standard care was compared with standard care in patients with metastatic castration-resistant prostate cancer. The radioligand therapy prolonged progression-free and overall survival. Adverse effects were more common, but quality of life was maintained.

Patients with cirrhosis are at increased risk for serious infections, including spontaneous bacterial peritonitis, multidrug-resistant infection, and infection with gut microorganisms. In-hospital mortality exceeds 50%. Empirical antibiotic coverage is used until a precise diagnosis can be made.

Stress incontinence is common among women but underdiagnosed. Effective initial interventions include weight loss in overweight or obese women and pelvic-floor muscle exercises. Other options include pessaries or surgery (most commonly midurethral mesh sling surgery) for women with bothersome symptoms not responsive to other interventions.

Most epistaxis is isolated or self-limited, but it is recurrent in approximately 16% of the general population, many of whom seek medical advice. This video demonstrates the evaluation of a patient with recurrent epistaxis and the technique used to perform nasal cauterization with silver nitrate in the office.