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Special Article
Medicare Spending in the MSSP
J.M. McWilliams and Others
In this analysis of spending in the Medicare Shared Savings Program, participation in shared-savings contracts was associated with savings for Medicare among physician groups but not among hospital-integrated organizations.
Sep 20 -
Original Article
Fingolimod vs. Interferon for Pediatric MS
T. Chitnis and Others
In 215 patients with a median age of 16 years, fingolimod was superior to interferon beta-1a in reducing relapses of multiple sclerosis and the accumulation of new lesions on MRI over a 2-year period. Seizures occurred in 5.6% of patients in the fingolimod group.
Sep 13
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Special Article
Medicare Spending in the MSSP
J.M. McWilliams and Others
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Perspective
Being PrEPared
R.H. Goldstein, C.G. Streed, Jr., and S.R. Cahill
Despite its proven benefits, preexposure prophylaxis against HIV (PrEP) has been prescribed to only a fraction of the population that would benefit from it. Stigma and limited awareness are substantial barriers to improving uptake in the communities at the highest risk.
Sep 19
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Perspective
Being PrEPared
R.H. Goldstein, C.G. Streed, Jr., and S.R. Cahill
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Perspective
Payment and Delivery-System Reform
H. Pham and P.B. Ginsburg
To truly redesign our health care payment and delivery system, we will have to take a holistic approach and move multiple levers in concert, rather than fiddling with individual factors serially and hoping for a coordinated effect.
Sep 19
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Perspective
Payment and Delivery-System Reform
H. Pham and P.B. Ginsburg
Original Research
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Original Article
Cardiovascular Safety of Lorcaserin in Obesity
E.A. Bohula and Others
In this cardiovascular safety trial, lorcaserin facilitated sustained weight loss without a higher risk of major adverse cardiovascular events than that with placebo in a high-risk population of overweight or obese patients.
Sep 20
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Original Article
Extended Thromboprophylaxis after Hospitalization
A.C. Spyropoulos and Others
Patients discharged from the hospital carry an increased risk of venous thromboembolism after discharge. A randomized trial of rivaroxaban for 6 weeks after hospital discharge had no significant effect on the risk of venous thromboembolism as compared with placebo.
Sep 20 -
Correspondence
Prevalence of Head Injury in the U.S.
A.L.C. Schneider and Others
In a survey of adults 40 years of age or older from the 2011–2014 National Health and Nutrition Examination Survey (NHANES) cohort, the prevalence of recalled head injury was 15.7%.
Sep 20
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Original Article
Extended Thromboprophylaxis after Hospitalization
A.C. Spyropoulos and Others
Clinical Practice and Review
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Case Records of the Massachusetts General Hospital
A Woman with Infertility
C. Coutifaris and Others
A 31-year-old woman with a history of primary amenorrhea and infertility was seen in the fertility center to discuss family-planning options. She had minimal body hair and a normal vagina; the cervix and uterus were absent. What is the diagnosis?
Sep 20 -
Clinical Practice
Primary Hyperparathyroidism
K.L. Insogna
Persons with mild hyperparathyroidism are at increased risk for renal stones, cortical bone loss, and fractures. Surgery is recommended for those younger than 50 years of age and those with osteoporosis, renal complications, or clinically significant hypercalcemia.
Sep 13 -
Perspective
Adolescents’ Use of “Pod Mod” E-Cigarettes
J.L. Barrington-Trimis and A.M. Leventhal
Use of a new e-cigarette product class called “pod mods” is rampant among young people. There is reason to be concerned that adolescents’ use of these products could bring a host of adverse health consequences to the current generation of adolescents and young adults.
Sep 20
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Case Records of the Massachusetts General Hospital
A Woman with Infertility
C. Coutifaris and Others
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Review Article
Antibody-Mediated Rejection of Solid-Organ Allografts
A. Loupy and C. Lefaucheur
This review focuses on current standards for management of antibody-mediated rejection in solid-organ transplant recipients and emphasizes advances that may ultimately lead to the development of precise, pathogenesis-based therapeutic approaches.
Sep 20 -
Perspective
Doctoring while Sick
A.P. Stern
For the author, practicing psychiatry has always been about empathy. But when he is diagnosed with stage 3 kidney cancer, he finds himself seeing his patients’ real and devastating problems as somehow less major than before.
Sep 20
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Commentary
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The FDA Amendments Act of 2007
J. Avorn, A. Kesselheim, and A. Sarpatwari -
The CMS Proposal to Reform Office-Visit Payments
Z. Song and J.D. Goodson -
Lorcaserin — Elixir or Liability?
J.R. Ingelfinger and C.J. Rosen -
Being PrEPared
R.H. Goldstein, C.G. Streed, Jr., and S.R. Cahill -
Payment and Delivery-System Reform
H. Pham and P.B. Ginsburg
Correspondence
- Prevalence of Self-Reported Head Injury in the United States
- Systemic AA Amyloidosis Caused by Inflammatory Hepatocellular Adenoma
- Sodium Thiosulfate and Cisplatin-Induced Hearing Loss
- Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis
- Cultured Cells and ROCK Inhibitor for Bullous Keratopathy
- Ivosidenib in IDH1-Mutated Acute Myeloid Leukemia
- Atezolizumab Treatment of Nonsquamous NSCLC
- Trends in Modern Phase 1 Oncology Trials
Who are the top three stakeholders with the primary responsibility for addressing obesity?
- Local, state, or federal government
- Individual patients
- PCP teams
- Individual primary care physicians
- Provider systems
- Community and nongovernmental organizations (e.g., nonprofits, foundations)
- Payers
- Private industry