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Editorial
Covid-19 Vaccines and Pregnancy — A Conversation with CDC Director Rochelle Walensky
E.J. Rubin and Others
In this audio interview conducted on April 16, the editors are joined by CDC director and infectious disease physician Rochelle Walensky to discuss a new study of Covid-19 vaccination in pregnancy, as well as a phase 3 trial of Ad26.COV2.S.
Apr 22 -
Original Article
Brief Report
Variant SARS-CoV-2 Infection after Vaccination
E. Hacisuleyman and Others
Mild Covid-19 symptoms developed in two fully vaccinated persons. Serum tests showed high titers of antibodies capable of neutralizing the wild-type strain of SARS-CoV-2 first identified in Wuhan, China, but sequencing of the virus isolates revealed novel variants. Some mutations in the receptor-binding domain of the spike protein were shared by the two variant strains.
Apr 21
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Editorial
Covid-19 Vaccines and Pregnancy — A Conversation with CDC Director Rochelle Walensky
E.J. Rubin and Others
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Original Article
Ad26.COV2.S Vaccine Efficacy against Covid-19
J. Sadoff and Others
Ad26.COV2.S is a replication-incompetent human adenovirus 26 containing the gene sequence that produces SARS-CoV-2 spike protein in a prefusion-stabilized conformation. In a randomized trial involving nearly 40,000 persons, vaccine efficacy was 66% against infection and 85% against severe–critical Covid-19. Efficacy against the variant first identified in South Africa was 64% against moderate disease and 82% against severe–critical disease.
Apr 21
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Original Article
mRNA Covid-19 Vaccine Safety in Pregnant Persons
T.T. Shimabukuro and Others
Preliminary data from the CDC “v-safe after vaccination health checker” surveillance system, the v-safe pregnancy registry, and the Vaccine Adverse Event Reporting System did not show any obvious safety signals among pregnant persons who received mRNA Covid-19 vaccines. More data are needed to better inform maternal, pregnancy, and infant outcomes.
Apr 21 -
Perspective
Advancing President Biden’s Equity Agenda
N.K. Aggarwal
On his first day in office, President Biden signed an executive order on advancing racial equity and supporting underserved communities. This policy presents an opportunity to implement lessons from health disparities research that target systemic racism.
Apr 22
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Original Article
mRNA Covid-19 Vaccine Safety in Pregnant Persons
T.T. Shimabukuro and Others
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Perspective
“Dangling” Accelerated Approvals in Oncology
J.A. Beaver and R. Pazdur
The FDA recently reevaluated accelerated approvals for 35 oncology indications for anti–programmed death ligand 1 antibodies, revealing that for 10 indications, the required trials did not end up confirming benefit and yet their marketing authorization continued.
Apr 21 -
Correspondence
Disposable E-Cigarette Use among U.S. Youth
T.W. Wang and Others
Despite efforts to curtail the use of e-cigarettes among youth, millions of middle and high school students use them. This study, which compares use in 2019 with use in 2020, shows that despite an overall decline, an increasing percentage of these students report using disposable e-cigarettes.
Apr 22
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Perspective
“Dangling” Accelerated Approvals in Oncology
J.A. Beaver and R. Pazdur
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CRISPR: Rewriting DNA and the Future of Medicine
130th Annual Shattuck Lecture
Jennifer A. Doudna, Ph.D., and Eric J. Rubin, M.D., Ph.D.

Original Research
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Original Article
Meeting of the American Academy of Dermatology
Bimekizumab versus Adalimumab for Psoriasis
R.B. Warren and Others
The interleukin-17A and interleukin-17F monoclonal antibody bimekizumab led to a higher incidence of clearance of psoriasis lesions than the anti-TNF drug adalimumab over a period of 16 weeks but was associated with oral candidiasis.
Apr 23
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Original Article
Meeting of the American Academy of Dermatology
Comparison of Two Interleukin-17 Inhibitors in Psoriasis
K. Reich and Others
Bimekizumab, which has activity against interleukin-17A and interleukin-17F, was compared in a randomized trial with secukinumab, which has activity against interleukin-17A only. Over 48 weeks, treatment with bimekizumab resulted in greater clearance of psoriasis but was associated with oral candidiasis.
Apr 23 -
Original Article
Sacituzumab Govitecan in Triple-Negative Breast Cancer
A. Bardia and Others
Patients with metastatic triple-negative breast cancer were treated with standard chemotherapy or the anti–Trop-2 antibody–drug conjugate sacituzumab govitecan. Patients receiving the drug conjugate had significantly longer progression-free and overall survival as well as more frequent myelotoxic effects and diarrhea.
Apr 22
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Original Article
Meeting of the American Academy of Dermatology
Comparison of Two Interleukin-17 Inhibitors in Psoriasis
K. Reich and Others
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Original Article
A Microbiota-Directed Food Supplement for Malnutrition
R.Y. Chen and Others
This study of the effect of a microbiota-directed supplement on the growth of young children with moderate acute malnutrition included tests of association between changes in growth and changes in the plasma proteome and fecal microbiota.
Apr 22Editorial Microbial Nourishment for Undernutrition
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Original Article
A Microbiota-Directed Food Supplement for Malnutrition
R.Y. Chen and Others
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Original Article
Tocilizumab in Severe Covid-19 Pneumonia
I.O. Rosas and Others
In this randomized trial involving 438 hospitalized patients with severe Covid-19 pneumonia, the use of the monoclonal antibody tocilizumab did not result in significantly better clinical status or lower mortality than placebo at 28 days.
Apr 22Original Article Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
Editorial Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup
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Original Article
Tocilizumab in Severe Covid-19 Pneumonia
I.O. Rosas and Others
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Learn More
Covid-19 Vaccine Resource Center
Practical guidance for your practice and patients
Clinical Practice and Review
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Case Records of the Massachusetts General Hospital
A Man with a Rash on the Scalp and Face
M.K. Yoon and Others
A 78-year-old man was admitted with a forehead and scalp rash and eyelid edema on the left side. The rash spread to the right side, with lesions appearing as punched-out erosions with hemorrhagic crust. The patient was unable to open his eyes; he began to have visual hallucinations and seemed confused. What is the diagnosis?
Apr 22 -
Review Article
Glomerular Filtration and Albuminuria
T. Benzing and D. Salant
Chronic kidney diseases generally arise from a disordered kidney filtration barrier within glomeruli. This review describes the roles of glomerular capillary pressure, the glomerular basement membrane, and podocytes in regulating glomerular filtration and permeability.
Apr 15 -
Clinical Implications of Basic Research
Fighting SARS-CoV-2 with Nanobodies
R. Sasisekharan
New therapies effective against SARS-CoV-2 are desirable. Could nanobodies represent an arrow in the quiver of therapeutic strategies to treat Covid-19?
Apr 22
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Case Records of the Massachusetts General Hospital
A Man with a Rash on the Scalp and Face
M.K. Yoon and Others
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Clinical Practice
Adrenal Incidentaloma
E. Kebebew
An adrenal mass discovered in testing for another condition (an “incidentaloma”) warrants biochemical tests to detect pheochromocytoma, excess cortisol, and, in a patient with hypertension, primary hyperaldosteronism. Imaging may distinguish benign from malignant lesions. Small nonfunctioning adrenal tumors with low CT attenuation generally do not warrant intervention or long-term follow-up.
Apr 22 -
Perspective
Nanima
M. Juthani-Mehta
I had always pitied people who end up in nursing homes and judged the families who put them there. But I had to face the fact that my parents could no longer give Nanima the care she required, and I was in no position to do so either. She needed somewhere safe to live.
Apr 22
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Commentary
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Australian Firearm Regulation at 25
J. Negin and Others -
Zoom Family Meeting
T.H. Lee -
Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup
E.J. Rubin, D.L. Longo, and L.R. Baden -
Microbial Nourishment for Undernutrition
W.S. Garrett -
“Dangling” Accelerated Approvals in Oncology
J.A. Beaver and R. Pazdur


