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Original Article
Trastuzumab Deruxtecan in HER2-Low Breast Cancer
S. Modi and Others
More than half of breast cancers express low levels of HER2. In a phase 3 trial, the antibody–drug conjugate trastuzumab deruxtecan resulted in longer progression-free and overall survival than the physician’s choice of chemotherapy among patients with HER2-low breast cancer.
Jul 07Editorial DESTINY-Changing Results for Advanced Breast Cancer
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Editorial
Covid-19 Update for July 5
Designing the Next Covid-19 Vaccine
E.J. Rubin, L.R. Baden, and S. Morrissey
In this audio interview conducted on July 5, the editors discuss upcoming changes to existing mRNA vaccines and the new viral variants they will address.
Jul 07 -
Correspondence
Omicron Neutralization from Vaccines in China
X. Zhao and Others
In this study, neutralization against the SARS-CoV-2 omicron subvariants was reduced with both the inactivated and ZF2001 vaccines. However, heterologous boosting and a longer interval between doses resulted in higher neutralization levels.
Jul 06
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Editorial
Covid-19 Update for July 5
Designing the Next Covid-19 Vaccine
E.J. Rubin, L.R. Baden, and S. Morrissey
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Clinical Decisions
Tympanostomy Tubes for Recurrent Otitis Media
C. Lee, D. Preciado, and A. Hoberman
This interactive feature about recurrent acute otitis media in a young child offers a case vignette accompanied by two essays, one supporting insertion of tympanostomy tubes and the other supporting conservative medical management. Vote and comment.
Jul 07 -
Perspective
Accelerated Approval
R.E. Sachs, J.M. Donohue, and S.B. Dusetzina
User-fee reauthorization creates new opportunities for the FDA to address issues with its accelerated-approval program, including the lack of evidence of clinical benefit for some products.
Jul 06
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Clinical Decisions
Tympanostomy Tubes for Recurrent Otitis Media
C. Lee, D. Preciado, and A. Hoberman
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Perspective
Physicians Spreading Misinformation on Social Media
R.J. Baron and Y.D. Ejnes
In light of widespread falsehoods about Covid-19 and its treatment and prevention, the American Board of Internal Medicine has informed doctors that disseminating misinformation is grounds for disciplinary sanctions.
Jul 07 -
Perspective
Institutionalizing Misinformation
P.A. Cohen, J. Avorn, and A.S. Kesselheim
A new bill, the Dietary Supplement Listing Act of 2022, would create the impression of reform in the supplement industry while leaving the current lax regulatory framework largely untouched.
Jul 07
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Perspective
Physicians Spreading Misinformation on Social Media
R.J. Baron and Y.D. Ejnes
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Learn More
Covid-19 Vaccine Resource Center
Practical guidance for your practice and patients
Original Research
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Original Article
Previous Infection and Vaccination in Covid-19
H.N. Altarawneh and Others
A study in Qatar assessed the effectiveness of previous infection, vaccination, and both against symptomatic SARS-CoV-2 caused by omicron BA.1 and BA.2 and against severe, critical, or fatal Covid-19.
Jul 07 -
Editorial
Science behind the Study
Genetic Modification in Xenotransplantation
E.G. Phimister
In a recent case of xenotransplantation, now described in the Journal, a porcine heart was transplanted into a human patient, an advance made possible through genetic alterations in the animal donor.
Jul 07
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Original Article
Previous Infection and Vaccination in Covid-19
H.N. Altarawneh and Others
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Correspondence
Decreased Neutralization of Omicron Subvariants
N.P. Hachmann and Others
In a small study involving 54 participants, omicron subvariants BA.2.12.1, BA.4, and BA.5 of SARS-CoV-2 were more likely to escape neutralizing antibodies induced by both vaccination and previous infection than were the prior omicron subvariants BA.1 and BA.2.
Jul 07
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Correspondence
Decreased Neutralization of Omicron Subvariants
N.P. Hachmann and Others
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Explore Recently Published Research from NEJM Evidence
Discover recently published original research articles — from important first-in-human studies to confirmatory trials — that validate or challenge prior clinical findings.
Clinical Practice and Review
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Review Article
The Vaccine-Hesitant Moment
H.J. Larson, E. Gakidou, and C.J.L. Murray
The proliferation of vaccine misinformation and its use for political purposes are placing a large number of people at risk in the Covid-19 pandemic and allowing the pandemic to continue.
Jul 07 -
Clinical Problem-Solving
The Young and the Breathless
J.J. Mayfield and Others
A previously healthy 18-year-old woman presented to a primary care provider with a 2-month history of headaches and midscapular pain. The midscapular pain was worse at night and lessened with exercise. What is the diagnosis?
Jul 07 -
Perspective
The Portal
S. Koven
What does it mean for a physician who has long maintained her privileged back channels to finally acquiesce to entering her own electronic medical record — and interacting with her doctors — through the patient portal?
Jul 07
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Review Article
The Vaccine-Hesitant Moment
H.J. Larson, E. Gakidou, and C.J.L. Murray
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Clinical Practice
Pulmonary Embolism
S.R. Kahn and K. de Wit
Evaluation of pulmonary embolism includes assessment of clinical probability and, if indicated, d-dimer testing. Most patients with low-risk pulmonary embolism can be treated with oral anticoagulants.
Jul 07 -
Case Challenge
A 17-Year-Old Girl with Fever and Cough
A 17-year-old girl presented during the Covid-19 pandemic with prolonged fever, cough that had progressed to hemoptysis, fatigue, pleuritic pain, and dyspnea. What is the diagnosis? Vote and comment. Find the answers in the full text of the case, to be published on July 13.
Jun 29
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Featured Multimedia
Commentary
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Physicians Spreading Misinformation on Social Media
R.J. Baron and Y.D. Ejnes
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Institutionalizing Misinformation
P.A. Cohen, J. Avorn, and A.S. Kesselheim -
DESTINY-Changing Results for Advanced Breast Cancer
S.A. Hurvitz -
The Future of Transplantation
J.L. Platt and M. Cascalho -
Genetic Modification in Xenotransplantation
E.G. Phimister -
The Portal
S. Koven -
Accelerated Approval
R.E. Sachs, J.M. Donohue, and S.B. Dusetzina
Correspondence
- Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5
- SARS-CoV-2 Infection in Patients with a History of VITT
- Nonoperative or Surgical Treatment of Acute Achilles’ Tendon Rupture
- The Increasing Incidence of Early-Onset Colorectal Cancer
- Prone Positioning of Intubated Patients with an Elevated BMI



