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Original Article
Maintenance Olaparib in Ovarian Cancer with Mutant BRCA
K. Moore and Others
Among women with advanced ovarian cancer with a BRCA mutation who had a response after platinum-based therapy, the median progression-free survival was approximately 3 years longer with the use of olaparib maintenance therapy for 2 years than with placebo.
Dec 27
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Original Article
Diagnostic Utility of Exome Sequencing in Kidney Disease
E.E. Groopman and Others
The utility of exome sequencing for most constitutional disorders in adults is unclear. In this study, exome sequencing in 3315 patients with chronic kidney disease yielded a genetic diagnosis in 307 cases (9.3%), with clinically important management implications for 89% of those reviewed.
Dec 26 -
Original Article
Nosocomial Transmission of Sphingomonas
R.C. Johnson and Others
In 2016, an unusual cluster of Sphingomonas koreensis infections was observed at the NIH Clinical Center. A subsequent investigation used whole-genome sequencing to determine that the transmission had been going on for a decade and that the hospital plumbing was the reservoir.
Dec 27
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Original Article
Diagnostic Utility of Exome Sequencing in Kidney Disease
E.E. Groopman and Others
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Perspective
Harder to Treat Than Leukemia
A.W. Loren
Woven into our language about the opioid epidemic is an implication that oncologists can hand out opioids as if there were no tomorrow. But for many people with cancer, there is now indeed a tomorrow — one that should be free of opioid addiction.
Dec 27
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Perspective
Harder to Treat Than Leukemia
A.W. Loren
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Perspective
A 24/7/365 Option for Combating the Opioid Crisis
G. D’Onofrio, R.P. McCormack, and K. Hawk
For people with opioid use disorder, an emergency department visit represents a critical, time-sensitive point at which initiating lifesaving treatment is possible. But there has been reluctance among emergency physicians to start patients on opioid-agonist treatment.
Dec 27
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Perspective
A 24/7/365 Option for Combating the Opioid Crisis
G. D’Onofrio, R.P. McCormack, and K. Hawk
Original Research
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Original Article
Antipsychotics for ICU Delirium
T.D. Girard and Others
In a multicenter trial in 566 patients with critical illness who had delirium, the use of haloperidol or ziprasidone, as compared with placebo, had no significant effect on the duration of delirium or coma. Side effects and extrapyramidal disorders occurred at similar rates in all groups.
Dec 27
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Original Article
Global Incidence of Stroke
The GBD 2016 Lifetime Risk of Stroke Collaborators
In 2016, the estimated lifetime risk of stroke from the age of 25 years onward (as calculated from the results of the GBD Study) was 24.9%. This estimate varies according to country, region, and national level of social development. The risk increased by 8.9% from 1990 to 2016.
Dec 20 -
Correspondence
Ancestry and Genetic Risk of Chronic Kidney Disease
G.N. Nadkarni and Others
The prevalence of APOL1 variants that confer a risk of chronic kidney disease in numerous American populations who share Western African genetic ancestry varies from 1% to 22%.
Dec 27
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Original Article
Global Incidence of Stroke
The GBD 2016 Lifetime Risk of Stroke Collaborators
Clinical Practice and Review
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Case Records of the Massachusetts General Hospital
A Woman with Recurrent Sinusitis, Cough, and Bronchiectasis
J.E. Mojica and Others
A 47-year-old woman was evaluated at the outpatient pulmonary clinic because of recurrent sinusitis with progressive cough and bronchiectasis. Examination of a sputum specimen was notable for the presence of 3+ to 4+ acid-fast bacilli. What is the diagnosis?
Dec 27 -
Clinical Implications of Basic Research
Hamartin and Kidney Development
J.R. Ingelfinger
A pivotal event in kidney development is the formation of nephrons, the number of which is inversely proportional to the risk of kidney disease. A recent study shows prolonged nephrogenesis and a 25% increase in nephrons in mice with reduced levels of hamartin in the kidney.
Dec 20 -
Perspective
Ramping Up the Response to Ebola
J.B. Nuzzo and T.V. Inglesby
Additional seasoned responders are needed to help control the Ebola outbreak in the Democratic Republic of Congo, but CDC staff have been pulled from the field owing to security concerns. These concerns need be addressed so that CDC staff can return.
Dec 27
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Case Records of the Massachusetts General Hospital
A Woman with Recurrent Sinusitis, Cough, and Bronchiectasis
J.E. Mojica and Others
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Clinical Practice
Glucocorticoid-Induced Osteoporosis
L. Buckley and M.B. Humphrey
Fracture-risk screening is indicated with initiation of glucocorticoids. If the risk is high because of age, bone mineral density, or the fracture risk assessment tool score, pharmacologic treatment is recommended; bisphosphonates are recommended as first-line treatment.
Dec 27 -
Perspective
Pregnant Women and the Ebola Crisis
L.B. Haddad, D.J. Jamieson, and S.A. Rasmussen
Ebola prevention and control measures in the current outbreak in the Democratic Republic of Congo have benefited from lessons learned from past outbreaks. Yet issues related to pregnant women have been largely ignored in these efforts.
Dec 27
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Commentary
Should nurse leaders be considered the equal of physician leaders in care delivery?