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Editorial
Covid-19 Update for September 13
Developing Mucosal Immunity to Covid-19
E.J. Rubin, L.R. Baden, and S. Morrissey
In this audio interview conducted on September 13, the editors discuss the role of a secreted IgA response in preventing SARS-CoV-2 infection, as well as vaccine effectiveness against the BA.4 and BA.5 strains.
Sep 15 -
Original Article
Omicron-Containing mRNA Vaccine Booster Immunogenicity
S. Chalkias and Others
When given as a second booster, a bivalent vaccine including sequences from the Wuhan-Hu-1 and omicron BA.1 viral strains induced higher levels of neutralizing antibodies against BA.4/5 subtypes than a Wuhan-Hu-1 booster.
Sep 16
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Editorial
Covid-19 Update for September 13
Developing Mucosal Immunity to Covid-19
E.J. Rubin, L.R. Baden, and S. Morrissey
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Original Article
Transcatheter Cardiovascular Therapeutics Conference
Cerebral Embolic Protection during TAVR
S.R. Kapadia and Others
In a randomized trial involving patients with aortic stenosis, the use of a cerebral protection device during TAVR did not decrease the risk of periprocedural stroke, but there were fewer disabling strokes.
Sep 17Editorial Does Capturing Debris during TAVR Prevent Strokes?
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Perspective
Closing the Public Health Ethics Gap
E. Parasidis and A.L. Fairchild
During the Covid-19 pandemic, public health officials have rarely obtained systematic input from ethicists. Doing so could help avert ineffective public health campaigns and further polarization.
Sep 15 -
Perspective
Finding a New Mantra
S.N. Heidari
During the frightening early months of the Covid pandemic, a palliative care physician finds herself silently mouthing a familiar mantra: I’m OK. We’re OK. We’ll be OK. But she is not OK.
Sep 15
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Perspective
Closing the Public Health Ethics Gap
E. Parasidis and A.L. Fairchild
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Perspective
FOSSIL-FUEL POLLUTION AND CLIMATE CHANGE
Protecting Pregnant People from Climate Change
S.A. Rasmussen and D.J. Jamieson
Failure to combat climate change poses a major health threat. Pregnant people and newborns are particularly vulnerable to climate-change–related health harms.
Sep 15 -
Correspondence
BNT162b2 Protection against Hospitalization in South Africa
S. Collie and Others
After either two doses or three doses of the BNT162b2 vaccine, effectiveness against the current sublineages of the omicron variant in South Africa waned rapidly with respect to protection against hospitalization.
Sep 14
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Perspective
FOSSIL-FUEL POLLUTION AND CLIMATE CHANGE
Protecting Pregnant People from Climate Change
S.A. Rasmussen and D.J. Jamieson
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Learn More
Covid-19 Vaccine Resource Center
Practical guidance for your practice and patients
Original Research
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Original Article
Aggressive or Moderate Hydration in Acute Pancreatitis
E. de-Madaria and Others
In a randomized trial involving patients with acute pancreatitis, early aggressive fluid resuscitation resulted in increased fluid overload without improvement in clinical outcomes.
Sep 15Editorial Fluid Resuscitation in Acute Pancreatitis — Going over the WATERFALL
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Original Article
Enteral Glutamine for Burn Injuries
D.K. Heyland and Others
In this trial involving critically ill patients with burn injuries, enteral glutamine supplementation did not reduce the time to discharge alive from the hospital.
Sep 15 -
Original Article
Polypill for Secondary Cardiovascular Prevention
J.M. Castellano and Others
Among patients with recent MI, therapy with a polypill containing aspirin, ramipril, and atorvastatin led to a lower incidence of major adverse cardiovascular events at a median of 3 years than usual care.
Sep 15Editorial The Polypill at 20 — What Have We Learned?
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Original Article
Enteral Glutamine for Burn Injuries
D.K. Heyland and Others
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Original Article
Anticoagulation in AF with Rheumatic Heart Disease
S.J. Connolly and Others
Among patients with rheumatic heart disease and atrial fibrillation who received a vitamin K antagonist or rivaroxaban, the rate of stroke, systemic embolism, MI, or death from vascular or unknown causes was lower with a VKA, without increased bleeding.
Sep 15Editorial Anticoagulation in Atrial Fibrillation and Rheumatic Heart Disease
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Original Article
Anticoagulation in AF with Rheumatic Heart Disease
S.J. Connolly and Others
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Explore Recently Published Research from NEJM Evidence
Discover recently published original research articles — from important first-in-human studies to confirmatory trials — that validate or challenge prior clinical findings.
Clinical Practice and Review
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Case Records of the Massachusetts General Hospital
A Man with Headache and Progressive Neurologic Dysfunction
D. Jayne and Others
A 59-year-old man was evaluated for headache and progressive neurologic dysfunction. Giant-cell arteritis and cranial nerve palsies had been diagnosed previously. Neuroimaging revealed pachymeningitis. What is the diagnosis?
Sep 15 -
Review Article
Personality Disorders
C. Sharp
The categories of personality disorders overlap, warranting an approach that considers fundamental underlying traits of these disorders, such as problems in self-regulation and maintenance of stable relationships.
Sep 08
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Review Article
Franklin H. Epstein Lecture
Covid-19 Vaccines — Immunity, Variants, Boosters
D.H. Barouch
The protective effects of vaccination and prior infection against severe Covid-19 are reviewed, with proposed directions for future research, including mucosal immunity and intermittent vaccine boost strategies.
Sep 15 -
Clinical Decisions
Managing Hyperglycemia in Non–Critically Ill Adults
L.L. Chang, G.E. Umpierrez, and S.E. Inzucchi
This interactive feature about management of hyperglycemia in non–critically ill inpatients who had been receiving metformin at home offers a case vignette accompanied by two essays, one supporting continuing metformin in the hospital and the other stopping metformin and initiating insulin therapy. Vote and comment.
Sep 15 -
Perspective
Professional Civil Disobedience
M.K. Wynia
When state laws banning abortion directly and immediately threaten the health of patients, should physicians collectively disobey them?
Sep 15
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Review Article
Franklin H. Epstein Lecture
Covid-19 Vaccines — Immunity, Variants, Boosters
D.H. Barouch
Featured Multimedia
Commentary
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The Law of Licensure and Quality Regulation
N. Cortez -
Pushing Back with Pills
L.A. Grossman -
The Seeds of Ignorance
W.J. Moss -
The Polypill at 20 — What Have We Learned?
T.J. Wang -
Anticoagulation in Atrial Fibrillation and Rheumatic Heart Disease
G.Y.H. Lip -
Fluid Resuscitation in Acute Pancreatitis — Going over the WATERFALL
T.B. Gardner
What are the top two biggest barriers to providing excellent care in urban/suburban settings?
- Adverse social determinants of health
- Lack of or inadequate health insurance
- Adverse social determinants of health
- Recruitment/retention of nurses
- Higher incidence of chronic diseases (e.g., type 2 diabetes)
- Primary care physician availability
- Difficulty of patient engagement
- Recruitment/retention of physicians
- High cost of capital
- Distance/travel time to facilities
- Suboptimal use of telehealth
- Don’t know