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Original Article
Randomized Trials of Ruxolitinib Cream for Vitiligo
D. Rosmarin and Others
In two phase 3, double-blind, placebo-controlled trials, the Janus kinase inhibitor ruxolitinib showed superiority to vehicle control in facial repigmentation of vitiligo.
Oct 20Editorial New Hope for Patients with Vitiligo
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Editorial
John Jarcho, M.D., 1957–2022
The Editors
Dr. John Jarcho, a former Deputy Editor of the Journal, died on October 13, 2022. He will be remembered by his colleagues for his warmth, dedication, humility, and skill as both an editor and a clinician.
Oct 19 -
Original Article
mRNA-1273 in Children 6 Months to 5 Years of Age
E.J. Anderson and Others
In a randomized, placebo-controlled trial involving children 6 months to 5 years of age, the mRNA-1273 vaccine was shown to be safe, and the elicited antibody responses were similar to those in young adults.
Oct 19
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Editorial
John Jarcho, M.D., 1957–2022
The Editors
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Editorial
Covid-19 Update for October 18
Covid-19: Where Are We Heading?
E.J. Rubin, L.R. Baden, and S. Morrissey
In this audio interview conducted on October 18, the editors talk about where Covid-19 stands today and where we may be heading.
Oct 20 -
Perspective
COP27 — Urgent Action Needed for Africa and the World
L. Atwoli and Others
Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present, and future impacts of climate change.
Oct 19 -
Perspective
Impending Relief for Medicare Beneficiaries
S.B. Dusetzina and H.A. Huskamp
For many Medicare beneficiaries, the Inflation Reduction Act will reduce out-of-pocket spending for retail prescription drugs, but some effects of the law will have to be carefully monitored by CMS.
Oct 20
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Editorial
Covid-19 Update for October 18
Covid-19: Where Are We Heading?
E.J. Rubin, L.R. Baden, and S. Morrissey
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Correspondence
Myocarditis and Covid-19 Vaccine in Adolescents
G. Witberg and Others
Among Israeli adolescents between 12 and 15 years of age who received the BNT162b2 vaccine, 9 cases of mild myocarditis were observed, mainly after the second dose.
Oct 19 -
Correspondence
Neutralization Escape by Omicron BA.4.6
N.P. Hachmann and Others
Neutralization titers against omicron subvariant BA.4.6 were lower by a factor of 2 to 2.7 than titers against subvariants BA.4 and BA.5 induced by infection or vaccination against SARS-CoV-2.
Oct 19 -
Perspective
Double Take
Atrial Fibrillation — What Is It and How Is It Treated?
E.M. Antman and Others
In this Double Take video for patients and families, physicians discuss the history, diagnosis, and treatment of atrial fibrillation, with a specific focus on catheter ablation therapy.
Oct 20
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Correspondence
Myocarditis and Covid-19 Vaccine in Adolescents
G. Witberg and Others
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Learn More
Covid-19 Vaccine Resource Center
Practical guidance for your practice and patients
Original Research
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Original Article
Blood-Pressure Targets in Comatose Patients after Cardiac Arrest
J. Kjaergaard and Others
This trial showed no significant difference in the percentage of patients who died or had severe disability or coma when higher or lower blood-pressure targets were used after an out-of-hospital cardiac arrest.
Oct 20Editorial Oxygenation and Blood-Pressure Targets in the ICU after Cardiac Arrest — One Step Forward
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Original Article
Oxygen Targets after Cardiac Arrest
H. Schmidt and Others
In comatose patients after out-of-hospital cardiac arrest, the incidence of death or severe disability was similar regardless of whether a restrictive or a liberal oxygenation strategy was used.
Oct 20 -
Original Article
Intermittently Scanned Glucose Monitoring
L. Leelarathna and Others
In persons with type 1 diabetes, intermittently scanned continuous glucose monitoring led to significantly lower glycated hemoglobin levels than participant monitoring with fingerstick testing.
Oct 20
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Original Article
Oxygen Targets after Cardiac Arrest
H. Schmidt and Others
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Explore Recently Published Research from NEJM Evidence
Discover recently published original research articles — from important first-in-human studies to confirmatory trials — that validate or challenge prior clinical findings.
Clinical Practice and Review
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Case Records of the Massachusetts General Hospital
A Man with Postoperative Cardiogenic Shock and Diffuse Rash
A.S. Desai and Others
A 76-year-old man was evaluated for persistent postoperative cardiogenic shock and new diffuse rash after undergoing mitral-valve replacement. The patient received oxacillin. Management decisions were made.
Oct 20 -
Clinical Implications of Basic Research
Recognition for Integrin Research
S.C. Fagerholm
This year’s Lasker Basic Medical Research Award goes to Drs. Hynes, Ruoslahti, and Springer for their discovery and characterization of a major class of adhesion molecules: the integrins.
Oct 20 -
Perspective
Trajectory
L.A. Ryan
By 9 p.m., we had lost the game. The trauma pager beeped incessantly. We gowned and gloved, became covered in blood, shed our bloody scrub skins, and started again.
Oct 20
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Case Records of the Massachusetts General Hospital
A Man with Postoperative Cardiogenic Shock and Diffuse Rash
A.S. Desai and Others
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Review Article
Myocarditis
C. Basso
Myocarditis has increased with Covid-19 and Covid-19 vaccines. Precise diagnosis relies on endomyocardial biopsy, but MRI and myocardial markers may be used. Treatment depends on the cause and degree of functional compromise.
Oct 20 -
Clinical Practice
FOSSIL-FUEL POLLUTION AND CLIMATE CHANGE
Treatment and Prevention of Heat-Related Illness
C. Sorensen and J. Hess
Climate change is resulting in higher temperatures and increased risks of mild to life-threatening heat-related illnesses. Risk can be reduced by counseling susceptible persons about risk-reduction strategies.
Oct 13
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Featured Multimedia
Commentary
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Impending Relief for Medicare Beneficiaries
S.B. Dusetzina and H.A. Huskamp
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COP27 — Urgent Action Needed for Africa and the World
L. Atwoli and Others -
New Hope for Patients with Vitiligo
L. Eidsmo -
Oxygenation and BP Targets after Cardiac Arrest
N. Nielsen and M.B. Skrifvars -
On- and Off-Ramps of Oncology Accelerated Approval
L.A. Fashoyin-Aje and Others -
Trajectory
L.A. Ryan
Correspondence
- Work Hours and Depression in U.S. First-Year Physicians
- IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination
- Brentuximab Vedotin in Advanced Hodgkin’s Lymphoma
- Anti-BDCA2 Antibody for Cutaneous Lupus Erythematosus
- Once-Weekly Dulaglutide for Treatment of Youths with Type 2 Diabetes
- Case 23-2022: A 49-Year-Old Man with Hypoglycemia



