Women with advanced endometrial cancer that progressed during platinum-containing therapy were randomly assigned to lenvatinib plus pembrolizumab or physician’s choice of chemotherapy (doxorubicin or paclitaxel). The median progression-free survival was 7.2 months with lenvatinib plus pembrolizumab and 3.8 months with chemotherapy; the median overall survival was 18.3 months and 11.4 months, respectively.

Previously untreated patients with advanced esophageal cancer were randomly assigned to receive chemotherapy alone, chemotherapy plus nivolumab, or nivolumab plus ipilimumab. Among patients with tumor-cell PD-L1 expression of 1% or greater, the two nivolumab regimens resulted in longer overall survival than chemotherapy. The side-effect profile was consistent with past reports on these agents.

Serum samples from 20 participants who had received two doses of the BNT162b2 vaccine and from 20 who had received three doses were assessed for ability to neutralize the omicron variant of SARS-CoV-2 in vitro. Neutralization activity was poor after two vaccine doses. However, substantial neutralization of the omicron variant was detected in samples from participants who had received three doses.

A 61-year-old man was evaluated after having jaundice, light-colored stools, dark urine, pruritus, fatigue, and a temperature of up to 39°C (without chills) for 1 week. He had dull pain in the right upper quadrant of the abdomen and had nausea but no vomiting. Six weeks before jaundice developed, he had been hospitalized with Covid-19. What is the diagnosis?

Travel to high altitude is increasing. The authors discuss physiological changes at high altitude, pretravel evaluation for common medical conditions, and the risks of high-altitude headache, acute mountain sickness, high-altitude pulmonary edema, and high-altitude cerebral edema.

A 14-year-old boy was admitted with fatigue, fever, joint pain, abdominal cramping, and diarrhea. He had been well until 2 weeks earlier, when fatigue and fever developed on his final day of summer camp. On the day of admission, he had pain in his shoulders and knees and a temperature of 39.2°C. What is the diagnosis?