In a trial of the glucose-lowering medications glargine, glimepiride, liraglutide, and sitagliptin added to metformin to maintain target glycated hemoglobin levels, all four decreased these levels.

In a secondary analysis comparing the effect of insulin glargine, glimepiride, liraglutide, and sitagliptin, added to metformin, on the incidences of microvascular complications and death, no material between-group differences were seen.

In a 6-month study in children while omicron was dominant, previous SARS-CoV-2 infection and the BNT162b2 vaccine lowered the risks of infection, hospitalization, and death, but protection against omicron declined rapidly.

In a randomized trial involving patients with aortic stenosis, the use of a cerebral protection device during TAVR did not decrease the risk of periprocedural stroke, but there were fewer disabling strokes.

This interactive feature about management of hyperglycemia in non–critically ill inpatients who had been receiving metformin at home offers a case vignette accompanied by two essays, one supporting continuing metformin in the hospital and the other stopping metformin and initiating insulin therapy. Vote and comment.

Burkitt’s lymphoma is a rapidly proliferating lymphoma of germinal-center B cells. Most patients are cured with chemotherapy and prevention of tumor lysis. Relapse and CNS involvement carry a poor prognosis.

The protective effects of vaccination and prior infection against severe Covid-19 are reviewed, with proposed directions for future research, including mucosal immunity and intermittent vaccine boost strategies.

A 59-year-old man was evaluated for headache and progressive neurologic dysfunction. Giant-cell arteritis and cranial nerve palsies had been diagnosed previously. Neuroimaging revealed pachymeningitis. What is the diagnosis?