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Original Article
Characteristics of Covid-19 in China
W. Guan and Others
In this study, researchers describe the clinical characteristics of coronavirus disease 2019 in a selected cohort of 1099 patients with laboratory-confirmed disease throughout China during the first 2 months of the current outbreak.
Feb 28Editorial Covid-19 — Navigating the Uncharted
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Editorial
February 24 NEJM Coronavirus Update
In this audio interview conducted on February 24, 2020, the editors discuss what’s needed to prepare for the ongoing spread of the virus outside China as well as the role of the Journal in disseminating critical information.
Feb 27 -
Perspective
Responding to Covid-19
B. Gates
Bill Gates writes that in any crisis, leaders have two equally important responsibilities: solve the immediate problem and keep it from happening again. In the case of the Covid-19 pandemic, the first point is especially pressing, but the second has crucial long-term consequences.
Feb 28
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Editorial
February 24 NEJM Coronavirus Update
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Editorial
Covid-19 — Navigating the Uncharted
A.S. Fauci, H.C. Lane, and R.R. Redfield
Anthony Fauci comments on the early clinical features and epidemiology of cases reported in Wuhan, China, along with current mortality data, noting that the outbreak is a stark reminder of the need for constant surveillance, prompt diagnosis, and robust research.
Feb 28 -
Case Challenge
A Man with Recurrent Abdominal Pain and Bloody Stools
An 89-year-old man with coronary artery disease presented after several months of bloody diarrhea, abdominal pain, and weight loss. What is the most likely diagnosis? Vote and comment. Find the answers in the full text of the case, to be published on March 11. On Twitter use #NEJMCases.
Feb 26
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Editorial
Covid-19 — Navigating the Uncharted
A.S. Fauci, H.C. Lane, and R.R. Redfield
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Perspective
Escaping Pandora’s Box — Another Novel Coronavirus
D.M. Morens, P. Daszak, and J.K. Taubenberger
With luck, public health control measures may be able to put the Covid-19 demons back in the jar. If they do not, we face a daunting challenge equal to, or perhaps greater than, that posed by the influenza pandemic of a century ago.
Feb 26 -
Clinical Decisions
Disclosure of Genetic Results of a Research Study
A. Castellanos and Others
This interactive feature about deidentified data in a nationwide genetic database offers a case vignette accompanied by essays that either support or discourage reidentifying the data and notifying participants who have actionable pathogenic mutations. Vote and comment.
Feb 20
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Perspective
Escaping Pandora’s Box — Another Novel Coronavirus
D.M. Morens, P. Daszak, and J.K. Taubenberger
Original Research
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Original Article
Deleterious Alterations in the Microbiota in Allogeneic HCT
J.U. Peled and Others
In this study, the gastrointestinal microbiome was serially monitored in patients undergoing allogeneic hematopoietic-cell transplantation at four centers. Lower microbial diversity was associated with poorer outcomes after HCT.
Feb 27
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Original Article
Pembrolizumab in Triple-Negative Breast Cancer
P. Schmid and Others
The addition of pembrolizumab to platinum-based neoadjuvant chemotherapy significantly increased the percentage of patients with a pathological complete response among patients with locally advanced triple-negative breast cancer. Side effects of the immunotherapy were added to the usual toxic effects of chemotherapy, but most patients completed planned treatment.
Feb 27 -
Original Article
Transcatheter versus Surgical AVR at 5 Years
R.R. Makkar and Others
Intermediate-risk patients with aortic stenosis were randomly assigned to undergo either transcatheter or surgical aortic-valve replacement. At 5 years, there was no significant difference between the two groups in the incidence of death or disabling stroke. The incidence of aortic regurgitation was higher with transcatheter AVR.
Feb 27Editorial TAVR at 5 Years — Rematch or Swan Song for Surgery?
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Original Article
Pembrolizumab in Triple-Negative Breast Cancer
P. Schmid and Others
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Original Article
Role of Vitamin E Acetate in EVALI
B.C. Blount and Others
In a study involving 51 patients with electronic-cigarette, or vaping, product use–associated lung injury in 16 states across the United States, vitamin E acetate was detected in samples of bronchoalveolar-lavage fluid from 94% of the patients but not in samples from a healthy comparator group.
Feb 20Editorial Cornering the Suspects in Vaping-Associated EVALI
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Original Article
Role of Vitamin E Acetate in EVALI
B.C. Blount and Others
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Original Article
Brief Report
Novel Mutation in VHL Linked to Systemic Abnormalities
S. Perrotta and Others
A young man with polycythemia, reduced growth rate, persistent hypoglycemia, and mitochondrial defects first appearing at birth was found to have a synonymous homozygous mutation in VHL (c.222C→A) that created a cryptic splice site leading to the production of a truncated VHL protein.
Feb 27
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Original Article
Brief Report
Novel Mutation in VHL Linked to Systemic Abnormalities
S. Perrotta and Others
Clinical Practice and Review
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Clinical Implications of Basic Research
Targeting Tumor and T-Cell Together
R.J. DeBerardinis
The newly diversified experimental strategies to treat cancer include those that involve tweaks to host immunity. A recently described strategy, conducted in mouse models of cancer, targets tumor cells while simultaneously boosting T-cell function.
Feb 27 -
Perspective
Transforming Global Health with AI
M.C. Mehta, I.T. Katz, and A.K. Jha
Artificial intelligence could revolutionize health and health care in low- and middle-income countries by addressing the large knowledge and judgment gaps that make care delivery poor. But for AI to fulfill this promise, some key challenges will need to be addressed.
Feb 27
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Review Article
Syphilis
K.G. Ghanem, S. Ram, and P.A. Rice
Over the past two decades, the incidence of syphilis has increased sharply. The courses of both untreated and treated disease can be unpredictable. This review presents guidance on clinical recognition of syphilis, diagnostic-test algorithms, and recommended treatment regimens.
Feb 27 -
Case Records of the Massachusetts General Hospital
A Man with a Mass in the Left Breast
S.J. Isakoff and Others
A 52-year-old man was referred to the hospital for management of a lump in the left breast. Mammography confirmed a round mass with irregular margins; ultrasonography of the left axilla revealed an abnormal lymph node. Biopsies showed intermediate-grade invasive ductal carcinoma and metastatic adenocarcinoma. Management decisions were made.
Feb 27 -
Health Policy Report
The ACA at 10 Years — Payment and Delivery Systems
D. Blumenthal and M. Abrams
In this second of two Health Policy Reports marking the 10th anniversary of the Affordable Care Act (ACA), the authors describe major payment and delivery system reforms and analyze the available evidence about the effects of the ACA on the quality and costs of health care.
Feb 26
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Review Article
Syphilis
K.G. Ghanem, S. Ram, and P.A. Rice
Commentary
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Influenza in U.S. Detention Centers
C. Foppiano Palacios, J.J. Openshaw, and M.A. Travassos -
Transforming Global Health with AI
M.C. Mehta, I.T. Katz, and A.K. Jha -
Unethical International Nurse-Staffing Agencies
P. Pittman and A.R. Pulver -
Is He OK?
E. Andrist -
Medical Journals and the Coronavirus
E.J. Rubin and Others -
TAVR at 5 Years — Rematch or Swan Song for Surgery?
E. Van Belle -
One in Four
E.C. Kaye
What are the top two reasons for health care organizations to reduce readmissions?
- To improve/optimize CMS STAR Ratings and/or CMS value-based payment bonuses
- To minimize/avoid CMS readmission penalties
- To meet care of quality measures in payer-provider contracts
- It’s the right thing to do for patients
- There is no good reason to reduce readmissions (e.g., readmissions are medically necessary)