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Original Article
Early Transmission Dynamics of 2019-nCoV
Q. Li and Others
The authors provide an epidemiologic analysis of the first 425 confirmed cases of infection with the novel coronavirus in Wuhan, China. This analysis provides estimates of the epidemic doubling time and the basic reproductive number and shows clear evidence of sustained human-to-human transmission.
Jan 29 -
Correspondence
2019-nCoV Transmission from Asymptomatic Patient
C. Rothe and Others
In this report, investigators in Germany detected the spread of the novel coronavirus (2019-nCoV) from a person who had recently traveled from China to Germany for a business trip. This transmission occurred before the apparent onset of illness in the index patient and was associated with additional transmission events in Germany.
Jan 30
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Original Article
Early Transmission Dynamics of 2019-nCoV
Q. Li and Others
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Original Article
Brief Report
First U.S. Confirmed Case of 2019-nCoV Infection
M.L. Holshue and Others
A healthy 35-year-old man who had visited Wuhan, China, presented with cough and fever that progressed to pneumonia. This report describes the diagnosis, clinical course, and management of the condition. The case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels.
Jan 31
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Original Article
Brief Report
A Novel Coronavirus in China
N. Zhu and Others
The authors report the emergence and isolation of a previously unknown betacoronavirus, the seventh member of the family of coronaviruses that infect humans, in Wuhan, China. Findings in three patients are described.
Jan 24Editorial Another Decade, Another Coronavirus
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Editorial
Medical Journals and the Coronavirus Outbreak
E.J. Rubin and Others
The editors announce expedited handling for submitted manuscripts describing the 2019-nCoV outbreak and make broad recommendations for speed, transparency, and data sharing.
Jan 27
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Original Article
Brief Report
A Novel Coronavirus in China
N. Zhu and Others
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Correspondence
Human-to-Human Coronavirus Transmission in Vietnam
L.T. Phan and Others
The authors describe transmission of 2019-nCoV from a father, who had flown with his wife from Wuhan to Hanoi, to the son, who met his father and mother in central Vietnam and shared a hotel room with them for 3 days. The findings suggest that the incubation period in the son may have been 3 days or less.
Jan 28 -
Perspective
A Novel Coronavirus Emerging in China
V.J. Munster and Others
A novel coronavirus, designated as 2019-nCoV, emerged in Wuhan, China, at the end of 2019. Although many details of the emergence of this virus remain unknown, it has put global public health institutions on high alert.
Jan 24
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Correspondence
Human-to-Human Coronavirus Transmission in Vietnam
L.T. Phan and Others
Original Research
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Original Article
H. pylori Treatment in Familial Gastric Cancer
I.J. Choi and Others
Among 1676 persons with H. pylori infection who had family members with gastric cancer, the incidence of gastric cancer over a median follow-up of 9.2 years was significantly lower among those who received eradication treatment for H. pylori infection than among those who received placebo.
Jan 30
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Original Article
Lung-Cancer Screening in the NELSON Trial
H.J. de Koning and Others
High-risk persons were screened for lung cancer in a population-based, randomized, controlled trial that involved volume-based nodule management for further testing. At 10 years of follow-up, lung-cancer mortality was significantly lower in the screening group than in the control group (2.5 vs. 3.3 per 1000 person-years among male participants).
Jan 29Editorial Mortality Reduction with Low-Dose CT Screening for Lung Cancer
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Original Article
Soluble Urokinase Receptor and Acute Kidney Injury
S.S. Hayek and Others
Soluble urokinase plasminogen activator receptor was measured in three patient cohorts at risk for acute kidney injury. Experimental models were used to assess suPAR as a therapeutic target. High suPAR levels were associated with acute kidney injury in both clinical and experimental settings.
Jan 30Editorial Risk Prediction for Acute Kidney Injury — Super Important, Now suPAR Easy?
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Original Article
Lung-Cancer Screening in the NELSON Trial
H.J. de Koning and Others
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Original Article
Transcatheter versus Surgical AVR at 5 Years
R.R. Makkar and Others
Intermediate-risk patients with aortic stenosis were randomly assigned to undergo either transcatheter or surgical aortic-valve replacement. At 5 years, there was no significant difference between the two groups in the incidence of death or disabling stroke. The incidence of aortic regurgitation was higher with transcatheter AVR.
Jan 29
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Original Article
Transcatheter versus Surgical AVR at 5 Years
R.R. Makkar and Others
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Original Article
Watching or Treating Pneumothorax
S.G.A. Brown and Others
More than 250 patients with uncomplicated, primary spontaneous pneumothorax were treated conservatively or by pleural intervention. In a complete-case analysis, reexpansion within 8 weeks occurred in 98.5% of the patients in the intervention group and in 94.4% of those in the conservative-management group.
Jan 30Editorial Clearing the Air — A Conservative Option for Spontaneous Pneumothorax
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Original Article
Watching or Treating Pneumothorax
S.G.A. Brown and Others
Clinical Practice and Review
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Interactive Medical Case
A Rapid Change in Pressure
K. D’Silva and Others
This interactive feature describes a patient who presents with progressive dyspnea on exertion, a nonproductive cough, fatigue, and unintentional weight loss following an international trip. Test your diagnostic and therapeutic skills.
Jan 30
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Clinical Practice
Hormone Therapy for Postmenopausal Women
J.V. Pinkerton
Hormone therapy is highly effective for the management of vasomotor symptoms in postmenopausal women; vaginal estrogen is used for genitourinary symptoms only. Hormone therapy is not recommended for primary or secondary prevention of coronary heart disease or dementia. Several nonhormonal therapies are also effective for vasomotor symptoms.
Jan 30 -
Clinical Implications of Basic Research
New Tool for Correcting Mutations
F.D. Urnov
Protein engineering has yielded a new, potent tool — in the form of a chimeric enzyme — for correcting genetic mutations. Proof of principle that this enzyme can correct different types of mutation, and even combinations of mutations, has been obtained in different types of mammalian cells.
Jan 30
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Clinical Practice
Hormone Therapy for Postmenopausal Women
J.V. Pinkerton
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Review Article
Effects of Intermittent Fasting on Health and Aging
R. de Cabo and M.P. Mattson
Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.
Dec 26 -
Review Article
Suicide
S. Fazel and B. Runeson
Suicide accounts for approximately 1.5% of deaths per year worldwide. Risk factors are known for populations, and psychological models address individual risks; the models and tools for assessing suicide risk are imperfect but provide some guidance.
Jan 16
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Review Article
Effects of Intermittent Fasting on Health and Aging
R. de Cabo and M.P. Mattson
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Case Records of the Massachusetts General Hospital
A Woman with Seizure Disorder and Wide-Complex Tachycardia
Kramer DB, Mihatov N, Buch KA, Zafar SF, Ruskin JN
A 52-year-old woman with refractory status epilepticus was admitted to the hospital. Despite treatment with a five-drug regimen, electroencephalography showed ongoing seizure activity. Fever, hypotension, a new wide-complex tachycardia, and diffuse global ventricular hypokinesis developed. What is the diagnosis?
Jan 30 -
Perspective
The Neglected Hospital
R. Rajbhandari and Others
Advancing emerging surgery, noncommunicable-disease, and quality agendas in global health will be possible only if investments are aimed at strengthening an undervalued component of health systems in low- and lower-middle-income countries: the district hospital.
Jan 30
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Case Records of the Massachusetts General Hospital
A Woman with Seizure Disorder and Wide-Complex Tachycardia
Kramer DB, Mihatov N, Buch KA, Zafar SF, Ruskin JN
Commentary
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The Neglected Hospital
R. Rajbhandari and Others
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Influenza in U.S. Detention Centers
C. Foppiano Palacios, J.J. Openshaw, and M.A. Travassos -
Is Obamacare Really Unconstitutional?
N. Bagley -
Clearing the Air — A Conservative Option for Spontaneous Pneumothorax
V.C. Broaddus -
Risk Prediction for Acute Kidney Injury — Super Important, Now suPAR Easy?
F. Tacke -
Fun
C.A. Colaianni -
Proposed Changes to Disclosures from the ICMJE
D.B. Taichman and Others
Correspondence
- One-Year Outcomes from ProACT
- Ticagrelor or Prasugrel in Acute Coronary Syndromes
- Statins for Familial Hypercholesterolemia from Childhood
- Identification from MRI with Face-Recognition Software
- Retraction: Retinal Hemorrhage from Blunt Ocular Trauma. N Engl J Med 2019;381:2252.
- Retraction: Relationship between Clinic and Ambulatory Blood-Pressure Measurements and Mortality. N Engl J Med 2018;378:1509-20.


