To the Editor: To recommend antiretroviral therapy (ART) as a policy to prevent transmission of the human immunodeficiency virus type 1 (HIV-1), it is critical to understand the risk of transmission through sex without condom use when the plasma viral ...

To the Editor: Rahman and colleagues (Aug. 11 issue)¹ found improved fluid drainage in patients with pleural infections and a reduced frequency of surgical referral and duration of hospital stay after combined therapy with intrapleural tissue plasminogen ...

To the Editor: Porter et al. (Aug. 25 issue)¹ report that chimeric antigen receptor–modified T cells proliferated and survived after infusion in a patient with chronic lymphoid leukemia, and they exerted potent antitumor activity. However, the authors ...

To the Editor: Jena et al. (Aug. 18 issue)¹ provide important insight into the medical malpractice quagmire. The data are presented and analyzed from the perspective of claims against individual physicians. In practice, an individual patient frequently ...

To the Editor: Mosaicism of an oncogenic AKT1 mutation causes Proteus syndrome, which is associated with epidermal nevi and an increased risk of cancer.¹ The occurrence of oncogenic mutations in mosaicism may increase a person's risk for malignant ...

Hypobaric hypoxia occurs during ascent to higher altitude. In this observational study of healthy lowland dwellers, intracellular red-cell forms of nitric oxide, S-nitrosohemoglobin, and iron nitrosyl hemoglobin increased strikingly during ascent to 5050 m.