Successful development of future targeted therapies will require the flexibility to rapidly evaluate combination regimens involving new targeted agents in a single development program. The FDA has therefore developed draft guidance on drug co-development.

Conflicting reports have led to confusion regarding secular trends for obesity in the United States. But even if data suggesting a plateauing of obesity rates offer some encouragement, obesity prevalence remains unacceptably high and has serious health implications.

In 2007, a bundled-payment approach to integrated chronic care was launched in the Netherlands, initially on an experimental basis with a focus on diabetes. The results provide lessons applicable to the U.S. concept of accountable care organizations.

A child with chest pain or tics, a toddler who is limping, a 12-year-old girl with abdominal pain or headaches, an infant whose fever does not respond to antibiotics — these are age-old challenges that pediatricians face. I have been teaching pediatrics ...