Dermal fibroblasts were obtained from members of a family with the long-QT syndrome and from controls and were used to generate pluripotent stem cells, which were then directed to differentiate into cardiac myocytes. The cells recapitulated characteristics of the long-QT syndrome.

In this secondary analysis of data from ADVANCE, severe hypoglycemia in patients with type 2 diabetes was associated with increased risks of macrovascular events, microvascular events, and death. Hypoglycemia may contribute directly or may be a marker of vulnerability.

Acute heart failure is a serious disorder often associated with progressive renal dysfunction. In this clinical trial, rolofylline, an adenosine A1–receptor antagonist, did not appear to benefit patients with acute heart failure and renal dysfunction.

A functional dystrophin transgene was delivered to skeletal muscle in patients with Duchenne's muscular dystrophy, an X-linked disorder resulting in progressive muscle weakness. The results showed a potential for T-cell immunity to self and nonself dystrophin epitopes.