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We agree with some of the points made by Stein and Ray but disagree about their conclusions. As clinicians, we recognize that fractures reduce the quality of life of patients with osteoporosis and increase the risk of coexisting conditions. Hence, we ...
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Rosen and Khosla review the arguments that are often advanced to provide support for placebo-controlled fracture trials in osteoporosis, which we discuss in our article. The undeniable crux of these arguments is that such trials are the most direct and ...
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