Patients with large abdominal aortic aneurysms were assigned to undergo endovascular repair or open surgical repair. Operative mortality was lower with endovascular repair, but at a median of 6 years, there was no significant difference between groups in total mortality or aneurysm-related mortality. There were more graft-related complications and reinterventions with endovascular repair.

Patients with large abdominal aortic aneurysms who were physically ineligible for open surgical repair were assigned to undergo endovascular repair or to receive no intervention. At a median of 3 years, aneurysm-related mortality was significantly lower with endovascular repair, but there was no difference in total mortality.

Patients with large abdominal aortic aneurysms were assigned to undergo open surgical repair or endovascular repair. At 6 years, the cumulative survival rates did not differ significantly between groups. The rate of secondary intervention was significantly higher with endovascular repair.

Patients were assigned to monitoring for rejection after cardiac transplantation either according to the standard practice of endomyocardial biopsies or with gene-expression profiling. At 19 months, the rates of rejection with hemodynamic compromise, graft dysfunction, death, or retransplantation were similar in the two groups, although the power of the trial was limited.

Susceptibility to Tourette's syndrome is known to have a genetic influence. This study, of a nonconsanguineous family in which the father and his eight children are affected by the disorder, implicates a deficit in L-histidine decarboxylase activity as one potential cause of the disorder.