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This clinical trial compared the effectiveness of an everolimus-eluting coronary stent with that of a paclitaxel-eluting stent in patients with coronary artery disease. Clinical outcomes at 1 year were superior with the everolimus-eluting stent in patients without diabetes, but not in patients with diabetes. These results are likely to influence clinical practice.
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In this randomized trial comparing vitamin E, pioglitazone, and placebo in adults without diabetes who had nonalcoholic steatohepatitis, vitamin E therapy was associated with a significantly higher rate of improvement in nonalcoholic steatohepatitis than was placebo (43% vs. 19%). Significant benefits of pioglitazone over placebo were shown for some secondary outcomes but not for the primary outcome.
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This study from a large academic hospital looked at medication errors before and after the implementation of technology for bar-code electronic medication-administration records. After implementation of the bar-code system, errors in transcription of medication orders were eliminated and errors in medication administration and potential drug-related adverse events were reduced.
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As of March 2010, illness caused by the 2009 H1N1 virus had occurred in almost all countries, with more than 16,000 deaths from laboratory-confirmed cases reported to the World Health Organization (WHO). The United States saw an estimated 59 million pandemic H1N1 illnesses, 265,000 hospitalizations, and 12,000 deaths. This review by WHO experts summarizes the virologic, epidemiologic, and clinical data on the 2009 H1N1 virus and assesses future directions.
A 45-year-old man presented to the emergency room after a syncopal episode that occurred while he was watching a baseball game. The syncopal event was preceded by the sudden onset of lightheadedness. He awoke after several seconds, without confusion. He noted nausea and diaphoresis but reported no chest pain before or after the event.
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