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Clinically relevant biomarkers for predicting the outcome of treatment in patients with Hodgkin's disease have not been established. In this study, gene profiling and immunohistochemical analysis were used to find such a marker. A strong association was found between a poor outcome of treatment and an increased number of CD68+ cells in the microenvironment of Reed–Sternberg cells. CD68, a marker of macrophages, outperformed the conventional International Prognostic Score and is available for immunohistochemical staining of diagnostic samples of Hodgkin's lymphoma.
In this national registry of data on cardiac catheterization, only 38% of elective, diagnostic coronary angiograms showed obstructive lesions, and 39% of angiograms were interpreted as showing no disease. The findings indicate a relatively low diagnostic yield of elective coronary angiography, a procedure that exposes patients to substantial radiation.
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This randomized, placebo-controlled, double-blind, multicenter trial assessed the safety and efficacy of the thyromimetic compound eprotirome in lowering the serum low-density lipoprotein cholesterol level in patients with hypercholesterolemia who were already receiving simvastatin or atorvastatin. Eprotirome was associated with decreased LDL levels in patients treated with statins.
Ventricular fibrillation and sudden death triggered by a blunt, nonpenetrating, and often innocent-appearing unintentional blow to the chest without damage to the ribs, sternum, or heart (in the absence of underlying cardiovascular disease) constitute an event known as commotio cordis. This review provides information on the clinical profile of this event, the physiological mechanisms underlying it, and steps that can be taken to prevent the event and to resuscitate the victim, should it occur.
A 49-year-old man was admitted to this hospital because of ascites. During the past 4 years, paresthesias and weakness of the lower legs and hands had developed, followed by difficulty breathing, peripheral edema, and during the past year, blurred vision, optic-disk edema, and ascites. Imaging studies subsequently revealed retroperitoneal lymphadenopathy and lytic lesions in the tibia and sacrum. A diagnostic procedure was performed.
This interactive Journal feature presents the case of an internist with a time-unlimited certificate from the American Board of Internal Medicine (ABIM) who is deciding whether to enroll in the Board's Maintenance of Certification program. Two recommendations, either of which could be considered correct, are presented. Which recommendation do you choose?
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After the January 12 earthquake in Haiti, the Port-au-Prince clinic of the Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO) became a refugee camp and an emergency field hospital (see slide show), in addition to ...
As I left an anesthesiology lecture on January 12, someone stopped me to ask whether I had checked on my family in Port-au-Prince. When he explained that there had been an earthquake, I breathed a sigh of relief — earthquakes, I reassured him, are a ...
