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In this 2200-person study conducted in China, the administration of an inactivated vaccine against the 2009 H1N1 virus achieved typical protective immune responses after one dose in subjects between 12 and 60 years of age, whereas two doses were required for younger subjects (3 to 11 years of age).
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In patients with heart failure and iron deficiency, intravenous iron therapy improved functional capacity and the quality of life. The benefit was similar in patients with anemia and those without anemia. Iron therapy may have a role in treating heart failure when iron deficiency is also present.
This review gives an account of recent advances in our knowledge of the molecular mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic mutations, occur in familial syndromes of colorectal cancer, whereas somatic mutations are the outstanding feature of sporadic colorectal cancer. Genetic changes drive the progression from adenoma to carcinoma and probably influence individual susceptibility and response to treatment.
This interactive Journal feature presents the case of a 57-year-old man with painful purple discoloration of three toes on his left foot, intermittent blurry vision, intermittent chest pain, fatigue, anorexia, drenching night sweats, and weight loss. Direct the investigation of the case, test your diagnostic and therapeutic skills, and compare your performance with that of others at NEJM.org.
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A 28-year-old woman was admitted to this hospital 2 days post partum because of cardiac failure. Four weeks earlier, at approximately 29 weeks' gestation, retrosternal chest discomfort developed, followed by shortness of breath, myalgias, and fatigue. Echocardiography revealed a pericardial effusion, with tamponade and biventricular hypokinesis. Despite pericardiocentesis and cesarean section at 32 weeks, her condition worsened. Radiographs obtained at this hospital showed a widened mediastinum; echocardiography revealed thickening of the pericardium and abnormal material surrounding the great vessels. A diagnostic procedure was performed.
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Establishing a diagnosis of 2009 pandemic influenza A (H1N1) virus infection in hospitalized patients can be challenging, especially in patients presenting late in their clinical course. Although real-time reverse-transcriptase polymerase chain reaction (...
There is a poor correlation between competence of care and malpractice lawsuits.1 The arbitrary-seeming nature of malpractice litigation places a dark cloud over all medical practice, encouraging wasteful defensive medical spending. According to a 1996 ...
