Deficiency of adenosine deaminase (ADA) causes a form of severe combined immunodeficiency disease. This study shows that gene therapy in the form of hematopoietic stem cells transduced with a viral vector containing the human ADA gene can restore immune function in patients with this disease.

This study examined the vital status and lifetime risk of end-stage renal disease in 3698 persons who donated a kidney between 1963 and 2007. The results indicate that survival and the risk of end-stage renal disease among carefully screened kidney donors appear to be similar to those in the general population. Most donors who were studied had a preserved glomerular filtration rate, normal albumin excretion, and an excellent quality of life.

About 20% of children with acute lymphoblastic leukemia (ALL) that arises from a B-cell progenitor have a relapse after induction chemotherapy. This study investigated genetic abnormalities in high-risk and low-risk ALL. Copy-number variations and mutations of IKZF1 were reproducibly found in high-risk ALL. The evidence suggests that the loss of function of IKZF1 has a role in resistance to chemotherapy in ALL.

Obesity is a modifiable risk factor for urinary incontinence. This study randomly assigned overweight and obese women with urinary incontinence to an intensive 6-month weight-loss program or to a structured education program. More intervention-group participants had clinically relevant reductions in the frequency of episodes of any incontinence, stress incontinence, and urge incontinence.