In this comparison of CT colonography and optical colonoscopy in 2600 asymptomatic study participants 50 years of age or older at 15 centers, 90% of large colorectal adenomas and adenocarcinomas detected by optical colonoscopy were also detected on CT colonography, and 10% were missed by CT colonography.

In this study of subjects who had no adenomas or cancers on baseline screening colonoscopy, advanced adenomas were detected in only 1.3% of those who returned for rescreening after 5 years. These findings support a rescreening interval of 5 years or longer for patients at average risk who have normal findings on colonoscopy.

In a multicenter trial, 20,332 patients who had recently had an ischemic stroke were randomly assigned to receive either telmisartan or placebo. All patients also received medications for blood-pressure control at the investigators' discretion. At a mean follow-up of 2.5 years, there was no significant difference between the two study groups in the rates of recurrent stroke or major cardiovascular events.

In this large clinical trial, aspirin plus extended-release dipyridamole was found to have an efficacy similar to that of clopidogrel in the prevention of recurrent stroke. However, aspirin plus extended-release dipyridamole resulted in more bleeding, including intracranial bleeding. The results will help guide therapy for secondary stroke prevention.