The West of Scotland Coronary Prevention Study demonstrated a significant reduction in coronary events after 5 years of treatment with pravastatin as compared with placebo. Participants were followed for an additional 10 years; approximately one third used statins. The rate of coronary events was reduced by 27% over the entire follow-up interval.

In this cohort study of Danish children at high risk for asthma, colonization of the airway at the age of 1 month with Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae, or a combination of these organisms, but not with Staphylococcus aureus, was associated with the development of asthma by the age of 5 years.

The tissue blocks from a large group of women who had participated in a randomized trial of the treatment of node-positive breast cancer were analyzed for the expression of HER2 and the estrogen receptor. A significant interaction was found between HER2 positivity and a benefit from the addition of paclitaxel after adjuvant treatment with doxorubicin plus cyclophosphamide.

This report describes three siblings with stop mutations in the muscle glycogen synthase gene, resulting in a severe reduction or complete absence of muscle and heart glycogen. One brother died suddenly; another had muscle fatigue, hypertrophic cardiomyopathy, and an abnormal exercise response.