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The use of repeat doses of antenatal corticosteroids in women at risk for preterm delivery has been reported to reduce neonatal morbidity, as compared with a single course. In this follow-up study of infants of women at risk for preterm delivery who were enrolled in a randomized trial comparing a single course of antenatal corticosteroid with repeat doses, there were no significant differences in survival free of major neurosensory disability or body size between the groups at 2 years of corrected age. These data provide reassurance regarding the use of repeat doses of antenatal corticosteroids in women who remain at risk for preterm delivery.
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In this follow-up study of infants of women at risk for preterm delivery who were enrolled in a randomized trial comparing a single course of antenatal corticosteroids with repeat courses, there were no significant differences in clinical outcomes. There were more cases of cerebral palsy in the repeat-corticosteroid group, although the difference between the groups was not significant.
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A genomewide association study of North American and Swedish patients with rheumatoid arthritis who were seropositive for autoantibodies against cyclic citrullinated peptide yielded susceptibility variants in the usual suspects: HLA-DRB1 and PTPN22. A new locus was also implicated: a SNP that lies between the TRAF1 and C5 genes.
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During an evaluation for low back pain, a 67-year-old man is found to have gynecomastia on the right side that is nontender on palpation. Other than a body-mass index of 32, the findings on physical examination are normal. His medical history is notable only for hyperlipidemia; his only medication is a statin. How should his gynecomastia be evaluated and managed?
A 51-year-old man was admitted to this hospital because of a pulmonary nodule. Helicobacter pylori infection had been diagnosed 5 years earlier, and a subtotal gastrectomy had been performed for adenocarcinoma of the gastric antrum and pylorus 2 years earlier. In the year before admission, pleuritic chest pain developed, and multiple pulmonary nodules and cysts were seen on computed tomography (CT). Two weeks before admission, a new pulmonary nodule was seen on follow-up CT. A diagnostic procedure was performed.
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