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May 24, 2007  Vol. 356 No. 21

Audio Summary of this Issue

Perspective
2125-2128
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On April 18, the Supreme Court held in Gonzales v. Carhart that a federal statute outlawing the use of “partial-birth abortion” is constitutional. R. Alta Charo writes that the decision thus opens the door to revisiting any number of state and federal ...

2128-2129

Dr. Michael Greene writes that the recent decision in Gonzales v. Carhart to uphold the Partial-Birth Abortion Ban Act of 2003 creates an intimidating environment surrounding pregnancy terminations at more advanced gestational ages.

Original Articles
2131-2142

This study of 636 cases of colorectal cancer culled from two large cohorts of participants who reported data on aspirin use showed that regular use of aspirin reduced the risk of having a colorectal cancer that expressed high amounts of COX-2, an enzyme affected by aspirin.

2143-2155

This multicenter, randomized clinical trial compared two surgical procedures — the Burch colposuspension and the autologous fascial pubovaginal sling — in women with urinary stress incontinence. Success rates (in terms of overall urinary-incontinence measures and stress-incontinence measures specifically) were higher at 2 years for the sling group, but this group also had greater morbidity. These findings inform decision making with respect to surgical treatment of stress incontinence and underscore the importance of surgical randomized trials.

2156-2164

Patients with out-of-hospital respiratory distress who received treatment from emergency medical services personnel with advanced-life-support training had a lower in-hospital mortality than those who received treatment from providers without this training. The difference may be in part attributable to advanced-life-support interventions. Whether the data are sufficient to justify broad implementation of such training is unclear.

Special Article
2165-2175

As compared with mortality in hospitals with high-level, high-volume neonatal intensive care units (NICUs), the mortality among very-low-birth-weight infants was higher at NICUs with lower levels of care and lower patient volumes. Although these data cannot prove cause and effect, the results suggest that increased regional consolidation of perinatal care is feasible and might reduce mortality among very-low-birth-weight infants.

Clinical Therapeutics
2176-2183
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A 44-year-old morbidly obese woman inquires about bariatric surgery, a treatment option for patients with a body-mass index of 40 or more (or of 35 or more when there are coexisting medical conditions). Bariatric surgery has been shown to result in substantial weight loss and resolution of associated conditions. A successful clinical outcome requires an experienced multidisciplinary management team and an informed patient who will follow a plan of long-term management and self-care.

Videos in Clinical Medicine
e21

    This video demonstrates the technique for placement of a central venous line in the internal jugular vein and considers complications and how to avoid them.

    Images in Clinical Medicine
    2184
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    A healthy 65-year-old man presented with a 4-month history of left flank pain and nocturia. Dermatologic examination revealed multiple eruptive seborrheic keratoses, which he reported had developed over the previous 1 to 2 years (Panels A and B). ...

    e22
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    In this 65-year-old man, a right internal jugular catheter was placed for management of congestive heart failure. There was difficulty removing the guidewire, requiring force to pull it out.

    Case Records of the Massachusetts General Hospital
    2185-2193

      A 61-year-old man was referred to the thoracic oncology service for management of a thymoma. Six weeks earlier, a mediastinal mass, 4 cm in diameter, had been detected on a computed tomographic scan obtained because of chest pain. A positron-emission tomographic scan showed increased tracer uptake in the area of the lesion. Biopsy specimens showed a World Health Organization type B1 thymoma. Physical examination was normal. A decision on management was made.

      Editorials
      2195
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      Although I am not a provider of reproductive medical services, I was alarmed to read of the recent decision of the Supreme Court in Gonzales v. Carhart. Why should I feel so concerned? The practical consequences of the “partial-birth abortion” bill are so ...

      2195-2198

      The compelling evidence that chronic use of aspirin or certain nonsteroidal antiinflammatory drugs (NSAIDs) can substantially lower the risk of colon cancer has important implications, especially because colon cancer is the second leading cause of cancer ...

      2198-2200

      Urinary incontinence is a common condition affecting 20 to 40% of older women.1 The two most common types of urinary incontinence are stress incontinence, the involuntary loss of urine resulting from increased abdominal pressures (such as with a cough or ...

      Health Law, Ethics, and Human Rights
      2201-2207

      In Gonzales v. Carhart, the Supreme Court ruled 5 to 4 that a physician can be prohibited from performing a particular medical procedure to abort a fetus, even if the physician believes the procedure is necessary to protect a woman's health. The author discusses the important implications of this decision for patients and physicians.

      Clinical Implications of Basic Research
      2208-2210

        Exposure of skin to ultraviolet light results in the synthesis of pro-opiomelanocortin (the precursor of melanin). A recent study implicates p53 in this process.

        Correspondence
        2211-2214

        To the Editor: Calverley et al. do not sufficiently emphasize some aspects of their study on the use of salmeterol and fluticasone in patients with chronic obstructive pulmonary disease (COPD) (Feb. 22 issue).1 Their study, called the Towards a ...

        2214-2218

        To the Editor: Ullmann et al. and Cornely et al. (Jan. 25 issue)1,2 report on posaconazole prophylaxis in patients with hematologic cancers. Ullmann et al. found that posaconazole was superior to fluconazole for protection against invasive aspergillosis, ...

        2218-2219

        To the Editor: In their report on the Randomized Trial of Embolization versus Surgical Treatment for Fibroids (REST), Edwards et al. (Jan. 25 issue)1 carefully discuss the benefits of uterine-artery embolization as compared with hysterectomy but do not ...

        2219-2223

        To the Editor: In his Perspective article on diabetes, Nathan (Feb. 1 issue)1 suggests that a newly approved dipeptidyl peptidase IV (DPP-IV) inhibitor, sitagliptin, “is one of the less effective glycemia-lowering drugs.” This contention may reflect a ...

        2223-2224

        To the Editor: In the article concerning monoclonal gammopathy of undetermined significance (MGUS) (Dec. 28 issue),1 Bladé disregards a complication that is especially important in clinical practice. Indeed, the problem of skeletal involvement in this ...

        2224-2225

        To the Editor: Isolated pulmonary-valve endocarditis is quite rare, but it shares demographic, clinical, and microbiologic features with the more-common tricuspid endocarditis.1 We describe a 35-year-old intravenous drug abuser who presented with ...

        Book Reviews
        2226

        The 1981 discovery by Adolfo J. de Bold of atrial natriuretic peptide, a peptide hormone secreted by the heart in response to volume expansion, revealed a homeostatic mechanism that counterbalanced the salt- and water-retaining actions of the renin–...

        2226-2227

        In 1989, two consecutive reports in Science described the cloning of vascular endothelial growth factor (VEGF) (the protein originally identified by Harold Dvorak and colleagues as vascular permeability factor), a landmark in the field of angiogenesis. ...

        2227-2228

        Thirteen years have elapsed since the first edition of this book was published. At that time, heart failure was just being recognized as a cardiovascular condition that had major effects on public health, and that recognition was probably the impetus for ...

        Correction
        2228

        Orotracheal Intubation Videos in Clinical Medicine, N Engl J Med 2007:356;e15.. In the PDF summary of the video, the third sentence under “Confirmation” should have read, “For children, you can use the following formula to estimate the proper depth of ...

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