Join the 200th Anniversary Celebration

Issue IndexA searchable index of tables of contents

Find An Issue

By Volume and Issue
By Date

Table of contents for

November 30, 2006  Vol. 355 No. 22

Audio Summary of this Issue

Perspective
2273-2275
  • Free Full Text
  • Audio

In July, 17 doctors gathered in New York to commemorate the 25th anniversary of the first reported AIDS cases. They listened to an oral history documenting the U.S. epidemic. Ronald Bayer and Gerald Oppenheimer discuss the July meeting, the shared ...

2276-2277

Ligula Hospital in Mtwara, Tanzania, has enrolled more than 700 patients as part of a national rollout of antiretroviral treatment and AIDS care. This collection of photographs by Dr. Beth Zeeman features the Ligula Hospital.

2278-2281

Osteonecrosis of the jaw is a potential complication of nitrogen-containing bisphosphonates. Dr. John Bilezikian asks whether there is a relationship between bisphosphonates and osteonecrosis of the jaw and what might explain it.

Original Articles
2283-2296
  • Free Full Text

Long-term antiretroviral therapy for the treatment of human immunodeficiency virus infection is associated with a substantial rate of complications. Structured interruption of antiretroviral therapy, in the setting of a preserved CD4+ count, has been considered in order to minimize these side effects. In this randomized study of 5472 patients, CD4+ count–guided intermittent use of antiretroviral drugs was found to be associated with increased rates of opportunistic disease, death from any cause, and severe adverse events, as compared with the continuous use of antiretroviral therapy.

2297-2307

In this placebo-controlled, randomized trial of pioglitazone in subjects with nonalcoholic steatohepatitis, pioglitazone was associated with improvements in the results of liver-function tests, hepatic fat content, and hepatic insulin sensitivity. As compared with placebo, pioglitazone significantly reduced the histologic abnormalities of steatohepatitis but did not significantly reduce fibrosis.

Special Articles
2308-2320

Hospitals have a variety of strategies to reduce the time from arrival at the hospital to intracoronary balloon inflation (door-to-balloon time) for patients who have acute myocardial infarction with ST-segment elevation. In a study of 365 hospitals, 28 institutional strategies were identified with the use of a field-tested questionnaire. These strategies were correlated with door-to-balloon times for individual patients as reported to the Centers for Medicare and Medicaid Services. Six strategies were associated with a significant reduction in the door-to-balloon time. The use of these strategies may improve outcomes for patients.

2321-2329

In this survey of institutional review board (IRB) members, 36% of those surveyed reported having relationships with industry. Although 86% believed that such relationships never adversely affected IRB-related decisions, a small number acknowledged that they had voted on a protocol sponsored by a company or a competitor to a company with which they had an association.

2330-2337

In this survey of patients enrolled in cancer trials, most were not worried about possible financial ties between researchers or medical centers and drug companies. Many patients wanted to be informed about financial ties or about the oversight system to protect against conflicts of interest, but few thought knowledge of financial ties would have influenced their decision to participate in the trial.

Clinical Practice
2338-2347
  • Free Full Text
  • Full Text Audio

A 51-year-old woman is having frequent and distressing hot flushes that interfere with her work and sleep, and vaginal dryness that makes sexual intercourse uncomfortable. She is otherwise healthy. How should her case be managed?

Images in Clinical Medicine
2348
  • Free Full Text

A 54-year-old man with a 3-year history of IgG myeloma, complicated by hypercalcemia, who was being treated with dexamethasone, lenalidomide, filgrastim, darbepoetin alfa, and pamidronate, presented with a 1-month history of severe bilateral jaw pain. He ...

e25
  • Free Full Text

This 68-year-old woman was referred because of erosive mucositis of the hard palate. The patient reported that she held the alendronate tablet in her mouth behind her upper denture plate before being able to swallow it.

Case Records of the Massachusetts General Hospital
2349-2357

A 19-year-old woman was evaluated in the gastroenterology clinic because of intermittent painless rectal bleeding and chronic iron-deficiency anemia. Eight months earlier, a papillary thyroid carcinoma had been treated with total thyroidectomy and administration of radioactive iodine (iodine-131). A diagnostic procedure was performed.

Editorials
2359-2361

Soon after the benefits of potent combination antiretroviral therapy were recognized in the late 1990s,1 clinicians understood that patients would need to be highly adherent to antiretroviral therapy and treated continuously with combination regimens. If ...

2361-2363

Mostly unrecognized before 1980, nonalcoholic fatty liver disease now affects all fields of clinical medicine and is the most common form of chronic liver disease in the United States.1 The prevalence of this disorder is expected to increase with the ...

2364-2365

It has been 27 years since the initial report of successful reperfusion of occluded coronary arteries with thrombolytic therapy in patients with acute myocardial infarction,1 and 20 years since the initial report of the feasibility and safety of primary ...

2365-2367

Whenever conflict of interest is mentioned in the context of clinical research, we tend to think of financial interests that may influence the ability of a person — particularly, a member of an institutional review board (IRB) — to make impartial ...

Correspondence
2368-2371

To the Editor: In the August 10 issue, Amarenco et al. report the results of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study.1 The study of high-dose atorvastatin for stroke offers promising results, but also raises ...

2371-2373

To the Editor: In the article by Arber et al. (Aug. 31 issue)1 about the Prevention of Colorectal Sporadic Adenomatous Polyps (PreSAP) trial, the percentage of patients with the combined end point of adjudicated serious cardiovascular events did not ...

2373-2375

To the Editor: Magnetic resonance imaging (MRI) is expensive and time-consuming, and it involves risks. From a Bayesian perspective,1 the use of MRI at term equivalent in preterm infants, as reported by Woodward et al. (Aug. 17 issue),2 is useful only if ...

2375-2376

To the Editor: The Case Record describing a 61-year-old man with facial pain was a clear presentation of the management of trigeminal neuralgia (July 13 issue).1 Patients who do not have a response to medical therapy or who have intolerable adverse ...

2376-2378

To the Editor: Regeneration of damaged brain tissue with neural stem cells is a promising strategy for reversing neurologic deficits.1 Superparamagnetic iron oxide nanoparticles have been used to label and track dendritic cells in the experimental ...

Book Reviews
2379-2380

It is generally agreed that the second edition of a textbook is rarely as good as the original; it is also generally agreed that the traditional textbook is dead. This superb new edition of Tropical Infectious Diseases trashes these notions. Tropical ...

2380-2381

While leafing through The Immune Response, a beautiful new textbook of immunology, I was reminded that the 30 years between 1955 and 1985, during which I was engaged in immunological investigations, were a time of extraordinary discovery. In the course of ...

2381-2382

In this unusual book, there are discussions of a very broad range of issues in medical education — from learning theory to educational technology, and from diversity in medicine to the economic challenges of academic practice and the relationships between ...