In this multicenter, placebo-controlled, randomized trial of postmenopausal women at high risk for a coronary event, raloxifene had no significant effect on the risk of primary coronary events, reduced the risk of invasive breast cancer and vertebral fractures, and increased the risk of fatal stroke and venous thromboembolism. A decision whether to use raloxifene for the prevention of breast cancer or vertebral fractures should be individualized, weighing benefits against potential risks.

In a cross-sectional analysis of the offspring cohort of the Framingham Heart Study, clinical heart failure in one or both parents correlated with a increased likelihood of echocardiographic evidence of left ventricular dysfunction, increased left ventricular mass, and increased internal left ventricular dimensions in the offspring.

In this double-blind, placebo-controlled study, soldiers at high risk for tick-borne relapsing fever were given doxycycline or placebo for five days after high-risk exposure to soft ticks. Postexposure prophylaxis was found to be highly effective in preventing symptomatic illness.

This multicenter study compared noninvasive Doppler measurement of the peak velocity of systolic blood flow in the middle cerebral artery with amniocentesis to determine bilirubin values according to the change in the optical density of amniotic fluid at a wavelength of 450 nm in the diagnosis of severe fetal anemia in Rh-alloimmunized pregnancies. As compared with invasive testing, Doppler ultrasonography of the middle cerebral artery had significantly better sensitivity and accuracy.