In women with early breast cancer, adjuvant therapy with epirubicin plus the standard combination of cyclophosphamide, methotrexate, and fluorouracil (CMF) was shown to improve both relapse-free and overall survival, as compared with the standard CMF regimen alone.

In a large, national program of colorectal-cancer screening in Poland, men were about twice as likely as women to have advanced neoplasia detected on colonoscopy. The yield of colonoscopy among men 40 to 49 years of age was similar to that among women 55 to 59 years of age (in these differing age groups, one advanced neoplasia detected for every 23 men and 22 women screened).

Fifteen patients with severe heart failure underwent implantation of left ventricular assist devices followed by a specific pharmacologic regimen. Eleven patients had sufficient myocardial recovery to permit explantation of the device, and eight of these patients were alive and free of heart failure or transplantation more than 4 years later.

Maternal periodontal disease has been associated with an increased risk of preterm birth and low birth weight. In this randomized trial, nonsurgical treatment of periodontitis (including scaling and root planing) in pregnant women improved periodontal disease but did not significantly alter rates of preterm birth, low birth weight, or fetal growth restriction.