To the Editor: Calin et al. (Oct. 27 issue)¹ report on genomic mutations within microRNA loci in patients with chronic lymphocytic leukemia (CLL). We believe that the frequency with which such mutations can be found was not accurately estimated and that ...

To the Editor: Mellinghoff et al. (Nov. 10 issue)¹ identified coexpression of epidermal growth factor receptor (EGFR) deletion mutant variant III (EGFRvIII) and the tumor-suppressor protein PTEN as a molecular signature in pretreatment glioblastoma ...

To the Editor: Recent reports have noted the presence of novel mutations of the epidermal growth factor receptor (EGFR) gene in small samples of DNA extracted from paraffin-embedded sections or laser-microdissected specimens.¹,² Nagahara et al.¹ reported ...

To the Editor: As African physicians who have experience in both the developing and the developed worlds, we believe that Mullan (Oct. 27 issue),¹ like others who have written about the metrics of the physician brain drain,² overlooks three important ...

To the Editor: Project planners who are seeking to cultivate a network of patients willing to provide their health information to genomic-cohort investigators, as described by Kohane and Altman (Nov. 10 issue),¹ cannot afford to ignore how increasing ...

To the Editor: We are concerned that Dr. Akbar and his colleagues, as reported in their letter to the editor (Sept. 29 issue),¹ used explanted cerebrospinal fluid shunt valves in their study of the susceptibility of these valves to malfunctions when ...

To the Editor: The recent three-month nationwide shortage of intravenous formulations of vitamin B₁ (thiamine) highlights the fact that only one company, American Pharmaceutical Partners, is manufacturing this lifesaving drug.¹ This shortage was the ...