To the Editor: Honer et al. (Feb. 2 issue)¹ showed that clozapine augmented with risperidone is unlikely to yield a moderate-to-large effect in patients with refractory schizophrenia. They conclude that there is no support for antipsychotic polypharmacy, ...

To the Editor: We question the selection by Elkins et al.¹ and Donaldson et al.² (Jan. 19 issue) of 7 percent hypertonic saline, which can result in bronchoconstriction, in these studies of therapy for cystic fibrosis. Elkins et al. report a fall of 94 ...

To the Editor: Freedman et al. (Jan. 12 issue)¹ has called attention to hazards for travelers. As the authors state, the study does not reflect the full epidemiology of travelers' diseases. There is a great danger that patients and practitioners who ...

To the Editor: The real shocker in the report by Papadakis et al. (Dec. 22 issue)¹ regarding disciplinary action by medical boards is the enormous prevalence of unprofessional behavior among medical students in the control group (nearly 20 percent). If ...

To the Editor: The article by Barrett and Parfrey (Jan. 26 issue)¹ raises two clinically relevant points regarding the use of metformin in patients at risk for contrast-medium–induced nephropathy. First, the patient described in the vignette should not ...

To the Editor: The use of aminoglycosides as powerful broad-spectrum, bactericidal, and nonallergenic antibiotics is limited by serious side effects, including irreversible hearing loss. Nevertheless, the drugs are commonly prescribed in some situations, ...

To the Editor: Previous reports have described an association between hydropic placentas and the occurrence of preeclampsia.¹,² One proposed explanation is that an enlarged placenta may cause a systemic inflammatory response by shedding an increased ...