To the Editor: Hampel and colleagues (May 5 issue)¹ suggest that a universal screening program for the detection of microsatellite instability in patients with colorectal cancer is feasible and probably desirable. However, it will not be inexpensive. We ...

To the Editor: Long-term antichlamydial antibiotic therapy did not alter the risk of cardiac events among patients with stable coronary disease, as reported by Grayston et al.,¹ or after an acute coronary syndrome, as reported by Cannon et al.² (April 21 ...

To the Editor: In their study, Ito and colleagues (May 12 issue)¹ observed reductions in both the activity and expression of histone deacetylases (HDACs), especially HDAC2, in patients with chronic obstructive pulmonary disease (COPD). In addition, the ...

To the Editor: The elegant work presented by Feldman et al. (May 5 issue)¹ shows that point mutations in codon 137 of the V2 vasopressin receptor (V2R) can result in either a loss-of-function mutation (R137H, which is associated with congenital ...

To the Editor: Two articles in the April 7 issue (Fridkin et al.¹ and Miller et al.²) deal with the subject of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infection. Fridkin et al. found that 6 percent of cases of MRSA infection ...

To the Editor: The emergence of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is of great concern.¹,² USA300, the predominant epidemic clone in numerous outbreaks in closed communities in the United States,² is also increasingly ...

In war, truth is the first casualty.

— Aeschylus (525–456 B.C.)

Severe acute respiratory syndrome (SARS) is the plague of the new millennium. The disease has caused tremendous social, economic, and political disruptions worldwide. In his book, Thomas ...

In 1793, a massive epidemic of yellow fever terrorized Philadelphia. Frustrated by fruitless trials of sundry remedies, Dr. Benjamin Rush finally hit on a putative cure: plentiful bloodletting and purging with the use of the potent laxatives calomel and ...

Traditionally, efforts to reduce the spread of human immunodeficiency virus (HIV) in the United States and elsewhere have focused on people who are at risk for becoming infected owing to their drug use or sexual behavior. The conceptual question has been, ...