To the Editor: A well-designed study aimed at showing the effect of cardiac resynchronization on mortality among patients with cardiac dyssynchrony, the Cardiac Resynchronization–Heart Failure (CARE-HF) Study (April 14 issue),¹ demonstrated improvements ...

To the Editor: Patients with lung cancer who respond to gefitinib have been reported to have somatic mutations consisting of deletions in exon 19 and the L858R mutation in exon 21 of the epidermal growth factor receptor (EGFR) gene.¹ In addition, a ...

To the Editor: A large amount of information suggests that mutations in the kinase domain of epidermal growth factor receptor (EGFR) are critical for the efficacy of EGFR kinase inhibitors.¹–³ However, the effect of EGFR mutations on the response to ...

To the Editor: Lynch et al.¹ and Paez et al.² correlated the presence of somatic mutations in the tyrosine kinase domain of the gene that encodes the epidermal growth factor receptor (EGFR) with responsiveness to gefitinib in non–small-cell lung ...

Most of us walk around oblivious to the time bombs that line our arteries. Indeed, atherosclerosis is, for the most part, a rather benign condition that affects, to some degree, virtually all the adult population both in developed countries and in many ...

The fact that cardiovascular disease, for the most part due to atherosclerosis, is the principal killer in Western societies is well known. However, how and why atherosclerotic plaques that develop over many decades rupture in an often unheralded manner — ...

Sir Thomas Lewis opined in 1933 that “the very essence of cardiovascular practice is the early detection of heart failure.” Heart failure at that time was a topic of substantial interest to physicians. In the past two decades that interest has been ...