To the Editor: Reyes and colleagues (March 24 issue)¹ should elaborate on the disadvantages, particularly the long-term side effects, of a regimen of doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone (ACVBP) in comparison with a regimen ...

To the Editor: Horstmann et al. (March 3 issue)¹ assume that a tumor response is of benefit to subjects in phase 1 oncology trials. This assumption is not valid. A complete or partial tumor response in a phase 1 trial is a surrogate end point, which for ...

To the Editor: The review of the serotonin syndrome by Boyer and Shannon (March 17 issue)¹ raises some questions. First, how many features make a diagnosis of the serotonin syndrome? This is especially relevant when a patient presents with nonspecific ...

To the Editor: A previously healthy 78-year-old woman presented with facial flushing, palpitations, diarrhea, and generalized weakness. The serum serotonin level was markedly elevated (2233 ng per milliliter; normal, <180), as was urinary excretion of 5-...

To the Editor: The ectopic corticotropin syndrome, a rare cause of chronic endogenous hypercortisolism, accounts for 15 to 20 percent of corticotropin-dependent Cushing's syndrome and 5 to 10 percent of cases of Cushing's syndrome overall.¹,² This ...

The association between thrombosis and cancer represents a challenge to scientists and physicians of various disciplines. From a clinician's point of view, progress in this field during the past several years has been substantial. In a patient presenting ...

Our understanding of the pathogenesis of multiple myeloma and the treatment of this condition have improved over the last decade to a degree unmatched by the advances of the preceding five decades. The publication of this book — edited by three ...

The pancreas never sounds a “lub dub,” makes no borborygmi, and is rarely palpable on physical examination. Nonetheless, gram for gram, it is just about the most active and efficient protein-synthesizing factory in the body. Moreover, when activated ...

With the global epidemic of obesity and its coexisting conditions, the need for effective obesity treatments has never been greater. Current behavioral and dietary therapies frequently lead to sufficient weight loss to reduce risk factors such as ...