Join the 200th Anniversary Celebration

Issue IndexA searchable index of tables of contents

Find An Issue

By Volume and Issue
By Date

Table of contents for

June 2, 2005  Vol. 352 No. 22

Perspective
2263-2265
  • Free Full Text
  • Audio

Physicians have always been concerned with how people survive trauma, writes Dr. Robert Jay Lifton. Less noted has been the experience of Americans as survivors of violent collective trauma. However, responses can be both painful and a potential source of ...

2266-2267

Dr. Ann Arvin writes that aging creates a special vulnerability to the often severely painful skin rash caused by varicella–zoster virus. The debilitating pain syndromes that accompany the reactivation of childhood herpes zoster have motivated the search ...

2268-2270

Type II collagen is a member of a family of collagens that form long fibers. Dr. Darwin Prockop explains that any substitution of a larger amino acid for one of the more than 300 "obligate" glycine residues distorts the long, rigid helix formed by the ...

Original Articles
2271-2284

Herpes zoster and postherpetic neuralgia occur more often with increasing age. In this controlled trial among 38,546 adults 60 years of age or older, vaccination with a live attenuated varicella–zoster vaccine reduced the incidence of postherpetic neuralgia by 66.5 percent (as compared with placebo) and the incidence of herpes zoster by 51.3 percent.

2285-2293

The gene encoding vitamin K epoxide reductase complex 1 (VKORC1) is the target of warfarin, and a variant of the gene may be associated with variations in dose requirements. This study reveals a strong association between VKORC1 haplotype and the warfarin dose among European Americans. It also suggests that VKORC1 variants may explain the variations in dose requirements among persons of different ancestries.

2294-2301

The gene encoding type II collagen, COL2A1, was found to be mutated in affected members of three families with an inherited form of avascular osteonecrosis of the femoral head. This finding will spur studies of this gene in persons with the idiopathic form of the disease.

2302-2313
  • Free Full Text

This randomized trial included almost 1500 women with breast cancer and positive axillary nodes and compared treatment with doxorubicin and cyclophosphamide combined with either fluorouracil or docetaxel. The rates of disease-free and overall survival were significantly higher among women in the docetaxel group.

Clinical Practice
2314-2324
  • Free Full Text

A 10-year-old girl with atopic dermatitis reports itching that has recently become relentless, resulting in sleep loss. Her mother has been reluctant to treat the girl with topical corticosteroids because she was told that they damage the skin, but she is exhausted and wants relief for her child. How should the problem be managed?

Review Article
2325-2336

    Brucellosis has been present for millennia and has managed to elude eradication, even in most developed countries. Brucellosis causes much clinical morbidity as well as an important loss of agricultural productivity in the developing world. In this era of international tourism, brucellosis has become a common imported disease in the developed world. This review article discusses the pathogenesis and treatment of the disease.

    Images in Clinical Medicine
    2337
    • Free Full Text

    A 49-year-old man reported fatigue, arthralgia, and headache, along with a two-day history of chest pain. Physical examination revealed a pulse of 38 beats per minute. What is the diagnosis?

    Clinical Problem-Solving
    2338-2342

      A 20-year-old man who had immigrated to the United States from Mexico three months earlier presented to the emergency department reporting weight loss and pain in his hip and the right side of his lower back. He had noted decreased appetite for several weeks and had unintentionally lost 16 kg.

      Editorials
      2344-2346

      A few years ago, I had zoster (shingles) — no surprise, since I was over 60 years of age, and zoster is usually a disease of later life. Fortunately, both the rash and the pain disappeared within a few days. I was grateful not to have to endure the ...

      2346-2348

      Chemotherapy, an integral component of adjuvant treatment for women with resected node-positive breast cancer, improves disease-free and overall survival in many patients. Older regimens include such combinations as cyclophosphamide, methotrexate, and ...

      Correspondence
      2349-2350

      To the Editor: Computer reminders such as the one described by Kucher and colleagues (March 10 issue)1 can draw attention to important situations, since medical errors frequently occur when physicians are busy, tired, or distracted.2,3 The real challenge,...

      2350-2353

      To the Editor: In the report by Rutkowski et al. (March 10 issue)1 regarding treatment of early childhood medulloblastoma with postoperative chemotherapy alone, 20 of 43 children under the age of three years (46.5 percent) had desmoplastic ...

      2353-2355

      To the Editor: Verhagen and Sauer (March 10 issue)1 emphasize that euthanasia is becoming acceptable medical practice for infants in the Netherlands in whom hopeless and unbearable suffering is present. Doctors are not all-knowing, but pediatric ...

      2355

      To the Editor: The medical mystery in the April 7 issue1 involved a radiograph (Figure 1) in a patient who had undergone four lifesaving procedures between 1949 and 2002. The radiograph shows remnants of a therapeutic pneumothorax for pulmonary ...

      2356

      To the Editor: Familial amyloidotic polyneuropathy is a fatal autosomal dominant disease caused by amyloidogenic genetic variants of transthyretin. The liver is the predominant source of circulating transthyretin, and liver transplantation is the only ...

      2357-2358

      To the Editor: Liver transplantation is considered to be an appropriate therapeutic option for hemophilia complicated by cirrhosis.1 Correction of deficiencies of factor VIII and factor IX by liver transplantation is well known.2 Factor XI deficiency is ...

      Book Reviews
      2359-2360

      This second edition of Pulmonary Circulation is timely. Nine years have elapsed since its first edition in 1996, years in which we have witnessed such major scientific advances as the description of the human genome (2001) and, directly relevant to the ...

      2360

      The lung is exceptional in that pathologic changes can be seen clearly in radiographs because of the air–tissue contrast. When bilateral diffuse, ill-defined shadows are seen, one begins to speculate on the cause — infection, inflammation, or neoplasm? ...

      2360-2361

      Angiographic observations in the early 1980s confirmed that acute coronary thrombosis was the proximate cause of acute myocardial infarction — seminal studies that led to revolutionary treatments for the recanalization of occluded vessels. However, during ...

      2362

      This book pays tribute to the adage “Hypertension goes with the kidney” by examining the relationship between renal function and blood pressure, from a perspective that is primarily clinical and therapeutic but is also grounded in epidemiology and ...

      Corrections
      2362

      Methicillin-Resistant Staphylococcus aureus Disease in Three Communities Original Article, N Engl J Med 2005:352;1436-1444.. In the Abstract on page 1436, the Methods and Results sections should have referred to “community-associated” infection, rather ...

      2362

      Prevention of Hepatitis B with the Hepatitis B Vaccine Clinical Practice, N Engl J Med 2004:351;2832-2838.. The brand name Pediarix (rather than Pediatrix) should have appeared in the right-hand column of page 2833, in lines 3 to 4 under the heading ...

      2362

      Modification of Human Hearing Loss by Plasma-Membrane Calcium Pump PMCA2 Original Article, N Engl J Med 2005:352;1557-1564.. On page 1557, lines 7 through 9 of the Summary should have read, “V586M was detected in two unrelated persons with increased ...

      2362

      Outcomes Associated with a Trial of Labor after Prior Cesarean Delivery Correspondence, N Engl J Med 2005:352;1718-1720.. In the letter by Smith, lines 18 through 20 of the first paragraph should have read, “. . . the numbers of infants who had a five-...