To the Editor: The trial conducted by Mayer et al. (Feb. 24 issue),¹ showing that recombinant activated factor VII (rFVIIa) is beneficial for treating acute intracerebral hemorrhage, for which treatment options are extremely limited, is very exciting. ...

To the Editor: List et al. (Feb. 10 issue)¹ report encouraging results with regard to the efficacy of lenalidomide, a thalidomide analogue, in the treatment of patients with myelodysplastic syndromes and symptomatic anemia whose condition failed to ...

To the Editor: Kobayashi et al. (Feb. 24 issue)¹ report that a second mutation in the gene encoding the epidermal growth factor receptor (EGFR), one resulting in a threonine-to-methionine substitution at amino acid position 790 (T790M), was associated ...

To the Editor: Sanders et al.¹ and Paltiel et al.,² in their reports on the cost-effectiveness of screening for HIV infection (Feb. 10 issue), have added another level of evidence in support of broader HIV testing. It appears that the benefits of routine ...

To the Editor: In his review of unhealthy alcohol use (Feb. 10 issue),¹ Dr. Saitz does not address the important role that biomarkers can play in identifying and treating alcohol-use disorders. At least some patients with alcohol-use disorders are unable ...

To the Editor: AIDS is a well-known predisposing condition for generalized histoplasmosis, which had been ruled out in the patient described in the Clinical Problem-Solving article by Goulet et al. (Feb. 3 issue).¹ Idiopathic CD4+ lymphocytopenia² is ...

To the Editor: Zidovudine was the first drug approved for the treatment of HIV infection and is still a mainstay of antiretroviral therapy. Patients taking zidovudine have an increase in the mean corpuscular volume, a variable that is often used to ...

Is it really worth $40 per pack to smoke cigarettes? According to Duke University health economists, $40 is the real cost that a 24-year-old smoker should consider each time he or she purchases a pack of cigarettes. This amounts to $220,000 for men and $...

On February 27, the Framework Convention on Tobacco Control came into force, 90 days after ratification by the 40th signatory to this first health treaty negotiated under the auspices of the World Health Organization. The treaty codifies policy approaches ...

Chronic sleep deprivation, which probably affects at least one third of American adults, causes daytime sleepiness and disrupts daily life. Episodes of acute sleep deprivation may be even more common and occur across a spectrum of ages and occupations. In ...

In the preface to this book, the authors point out that for thousands of years humans have used psychoactive substances to modify their perceptions and mood. Indeed, some observers believe that such behavior may be a defining characteristic of the human ...

Elevated Plasma Factor VIII and D-Dimer Levels as Predictors of Poor Outcomes of Thrombosis in Children Original Article, N Engl J Med 2004:351;1081-1088.. On page 1084, in Table 1, the range for factor VIII among patients who had no initial elevation in ...

Amiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure Original Article, N Engl J Med 2005:352;225-237.. On page 226, in the right-hand column, line 8 of the first full paragraph should have read “aldosterone-receptor blocker,...

U.K. Controlled Trial of Intrapleural Streptokinase for Pleural Infection Original Article, N Engl J Med 2005:352;865-874.. On page 870, in Figure 1, the number of patients receiving placebo who completed the trial should have been 221, not 206, as ...