Issue IndexA searchable index of tables of contents
Find An Issue
Table of contents for
May 12, 2005 Vol. 352 No. 19
In asymptomatic French men, the heart-rate profile during exercise testing was found to be predictive of the subsequent risk of sudden death. Specifically, a higher resting heart rate, a lower increase in the heart rate during exercise, and a slower decline in heart rate during recovery from exercise were associated with an increased risk of sudden death. The authors speculate that the heart-rate profile of high-risk patients may be due to an underlying autonomic imbalance.
Circulating osteoblast-lineage cells have been considered rare. This study used new methods to show that osteoblastic cells are present in large numbers in peripheral blood in adult men. Furthermore, the concentration of cells increases markedly in adolescent boys during pubertal growth and in adult men after fractures. Thus, osteoblast-lineage cells circulate in physiologically significant numbers, possibly representing a previously unrecognized circulatory component of the process of bone formation.
- Free Full Text
The balance between histone deacetylase activity and histone acetyltransferase activity is one of the mechanisms controlling and limiting inflammatory cell activity. These investigators show that patients with chronic obstructive pulmonary disease (COPD), as compared with normal subjects and patients with asthma, cystic fibrosis, or pneumonia, had reductions in histone deacetylase activity. Greater reductions were observed in patients with more severe disease.
- Free Full Text
Men with early prostate cancer were randomly assigned to undergo radical prostatectomy or watchful waiting. Ten-year estimates of the risks of death from prostate cancer, of distant metastasis, and of local progression all favored radical prostatectomy over watchful waiting for men younger than 65 years.
- Free Full Text
Childhood cerebral folate deficiency is a disabling neurologic disorder in which folate is reduced in the cerebrospinal fluid but not in the blood. The usual signs of folate deficiency are therefore absent. This study showed that children with cerebral folate deficiency produce autoantibodies that block the binding of folate to the folate receptor. Very high doses of folate resulted in clinical improvement in some children.
A 38-year-old man with a history of ulcerative colitis had fever, arthralgias, leg pain, purpuric skin lesions, and blurred vision within two weeks after excision of a pilonidal cyst followed by treatment with antibiotics. Examination disclosed palpable purpura of the lower leg and retinal hemorrhages and exudates. During his hospitalization, abdominal and testicular pain and hematochezia developed. Diagnostic procedures were performed.
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
