To the Editor: Stampfer et al. (Jan. 20 issue)¹ suggest that “women who consume up to one drink per day have less cognitive impairment . . . than nondrinkers,” on the basis of the authors' data from the Nurses' Health Study and findings reported in the ...

To the Editor: Nguyen et al. (Feb. 3 issue)¹ report on the effect of the U.S. varicella vaccination program on disease-related mortality. The effectiveness of such programs also includes reducing severe varicella-associated complications. In Italy, from ...

To the Editor: Falini et al. (Jan. 20 issue)¹ report an abnormal cytoplasmic localization of nucleophosmin (NPM) in 35 percent of specimens from patients with acute myelogenous leukemia. In these patients the NPM gene was mutated, which resulted in a ...

To the Editor: We believe Meyerhardt and Mayer's discussion of regional, targeted therapies for colorectal cancer (Feb. 3 issue)¹ is incomplete. Regional infusion of interleukin-2 or interferon alfa through the hepatic artery, combined with chemotherapy, ...

To the Editor: In regard to the review of insulin analogues by Hirsch (Jan. 13 issue),¹ recurrent hypoglycemia is a major impediment to the achievement of good metabolic control, as defined by the Diabetes Control and Complications Trial.² Furthermore, ...

To the Editor: We report a case of asymptomatic dissection of the descending aorta (type B aortic dissection) with silent renal hypoperfusion. A small, nonfunctioning kidney and a contralateral hypertrophied kidney were identified after symptomatic ...

To the Editor: An important concern with respect to protecting human research participants is that institutional review boards (IRBs) have insufficient resources.¹ However, there are few reports of the actual costs of IRB review.²–⁴ To estimate the cost ...

When I was asked to review this book, I was taken aback, since I truly didn't understand what “infections of leisure” are. The title, although playful, does not quite capture the scholarliness of this multiauthored book, which is published by the American ...

In Howard Markel's engaging book, the second word of the title is a good clue that the author writes for the general reader rather than for the specialist. The book contains an introduction and an epilogue, with each of the six intervening chapters ...

At the start of the 20th century, tuberculosis was the second leading cause of death in the United States. One hundred years later, it does not figure among the top 20 causes. Improvements in housing and sanitation, decreased crowding, and the ...

During the past decade, there has been a substantial rise in the number of antibiotic-resistant infectious organisms. Antimicrobial resistance is important because of its effect on the success and cost of antimicrobial treatment and on the treatment of ...