To the Editor: Ridker and colleagues (Jan. 6 issue)¹ suggest that statin therapy be targeted to achieve a C-reactive protein (CRP) level of less than 2.0 mg per liter in patients with a recent acute coronary syndrome. Having examined the data presented ...

To the Editor: Paik et al. (Dec. 30 issue)¹ imply that their multigene assay provides more objective and reproducible information than an assigned tumor grade. Any RNA-based gene-expression profile of neoplasms is heavily dependent on tumor cellularity. ...

To the Editor: Rappley's review of attention deficit–hyperactivity disorder (Jan. 13 issue)¹ omits important diagnoses that can mimic attention-deficit disorders — sleep disorders and convulsive disorders. Increased daytime behavioral problems occur with ...

To the Editor: As noted by Rupprecht and Gibbons (Dec. 16 issue),¹ delay before postexposure prophylaxis against rabies is initiated may result in treatment failure and death.² The incubation period for rabies in dogs could be much longer than 10 days. ...

To the Editor: In Case 38-2004 (Dec. 16 issue),¹ Richardson et al. provide an excellent discussion of the treatment options available for patients with multiple myeloma. In my opinion, the diagnostic workup for the patient is missing two important tests ...

To the Editor: In reply to the letter from Grass (Jan. 13 issue),¹ we would like to clarify that www.clinicaltrials.gov was expanded in October 2004 to allow for the registration of any clinical trial that has been approved by a human subjects review ...

To the Editor: Recent studies suggesting that C-reactive protein (CRP) may be an important risk marker for cardiovascular disease have stimulated the demand for testing. Nevertheless, many physicians may be unfamiliar with high-sensitivity CRP ...

To the Editor: Hyperthermia has long been recognized as a cause of altered mental status after a marathon, but in recent years exercise-associated hyponatremia has become increasingly common.¹ In 2003, there was an unexpected increase in the number of ...

Irrespective of the difficulty in determining its incidence, misconduct in research — fraud, falsification, and plagiarism — has a corrosive effect on the scientific enterprise. It violates the norms of scientific integrity, leads researchers down ...

Armed with support from the Robert Wood Johnson Foundation, Deyo and Patrick make a well-documented — if depressing — argument that doctors, scientists, and laypersons alike are far too easily seduced by industry hype for merely new (as opposed to truly ...

The controversy at the center of this book regarding the use of placebo in trials in developing countries came to light in 1997. The studies in question were evaluating the efficacy of zidovudine in the prevention of perinatal transmission of HIV, even ...

The essays in this book arose from a conference dedicated to the “History of Human Experimentation during the Twentieth Century,” held in 2001 at the University of Lübeck in Germany. Eight of the 23 contributors (including the editors) live in Germany; ...