To the Editor: The analyses presented by Danesh and colleagues (April 1 issue)¹ do not support their conclusion that C-reactive protein is only a moderate risk factor for coronary heart disease. First, their comparison of risk factors relies on the odds ...

To the Editor: The article by Hviid et al. (April 1 issue)¹ that suggests no link between childhood vaccination against measles, mumps, and rubella and type 1 diabetes has an important limitation that is all too common in clinical research. The study ...

To the Editor: In the pursuit of scientific truth, one of the most basic principles is the rigorous exclusion of preexisting bias. Without such exclusion, scientific investigation and experimentation have no validity. Blackburn's account of the recent ...

To the Editor: In their review article, Ginès et al. (April 15 issue)¹ state that in patients with large-volume ascites, the “serum creatinine concentration is normal or only moderately higher than normal, indicating that the glomerular filtration rate ...

To the Editor: In the review of pediatric palliative care by Himelstein et al. (April 22 issue),¹ it clearly is impossible to detail patient care in such a wide population. Thus, it is appropriate to mention one drug in each group, even though morphine, ...

To the Editor: With the recent decision of the Food and Drug Administration to ban the sale of ephedra in the United States, a broad discussion of the uses, risks, and regulation of herbal preparations has been kindled in the news media. We report a case ...

On Charles Darwin's birthday — February 12 — in 2001, two groups of scientists announced simultaneously that the human genome sequence had been completed. The public consortium, involving teams from six countries, published its results in Nature and made ...

Roy Porter died too young. One of the most distinguished and prolific medical historians of the day, Porter had recently taken early retirement from the Wellcome Trust Centre for the History of Medicine at University College London when, in the spring of ...

Sex Determination and Differentiation Review Article, N Engl J Med 2004:350;367-378.. On page 373, lines 22 through 25 in the first full paragraph of the right-hand column should have read, “patients with a translocation in the distal arm of chromosome ...

Case 5-2004: A 57-Year-Old Man with Slurred Speech and Left Hemiparesis Case Records of the Massachusetts General Hospital, N Engl J Med 2004:350;707-716.. On page 713, in the right-hand column, Panels A and B of Figure 5 should have been transposed. In ...