To the Editor: Merck has been proactive and conscientious in evaluating the cardiovascular profile of rofecoxib (Vioxx); Dr. Topol's remarks to the contrary in his Perspective article (Oct. 21 issue)¹ are false. First, his description of the time line ...

To the Editor: Marcellin and colleagues (Sept. 16 issue)¹ report that patients with hepatitis B e antigen (HBeAg)–negative chronic hepatitis B had higher rates of a sustained response to treatment with peginterferon alfa-2a than with lamivudine.¹ HBeAg-...

To the Editor: The Journal's support (Sept. 23 issue)¹ for the proposal of the National Institutes of Health (NIH) to make the results of NIH-sponsored research more readily available to the public² is commendable, as is its policy of making articles ...

To the Editor: Wang and Bashore's statement that physical examination provided “little guidance” in the case described in their Clinical Problem-Solving article (Sept. 2 issue)¹ is challenging in its omissions. Admittedly, the patient's extreme obesity ...

To the Editor: In reviewing the differential diagnosis in the case of a woman with disturbances in gait, cognition, and autonomic function, Schlossmacher provides a scholarly discussion of multiple-system atrophy (Aug. 26 issue),¹ but he errs by ...

To the Editor: Recent reports suggest that mutations in the epidermal growth factor receptor (EGFR) gene predict sensitivity to EGFR kinase inhibitors. In particular, patients with lung cancers containing mutations in the EGFR kinase domain have had ...

Although one might expect a book about generosity in medicine to involve a discussion of charity in health care, Arthur W. Frank engages the reader as a person who might alternatively be a patient or a physician. The Renewal of Generosity is about a ...

Death with dementia challenges a society not only to rethink but also to revalue its health care system. Moreover, as Ethical Foundations of Palliative Care for Alzheimer Disease reveals, care for persons dying with dementia exposes bioethics as a ...

In the past two decades, public and professional debates over the procurement and allocation of solid organs for transplantation have led to specific changes in policy and to organizational reforms. However, transplantation procedures for nonorgan tissues ...

In 1971, I was 10 years old and growing up in Brooklyn, New York. I was never a good eater, and the summer of that year was no different. Every dinner at the small dinette was an interminable ordeal punctuated by my mother's insistent plaint, “Eat, Jerry. ...

Premature Birth and Later Insulin Resistance Original Article, N Engl J Med 2004:351;2179-2186.. On page 2179, line 11 under Results, and on page 2184, in Table 3, under the column heading Premature Appropriate-for-Gestational-Age Group, the 95 percent ...

Hypocalciuric Hypercalcemia and Autoantibodies against the Calcium-Sensing Receptor Correspondence, N Engl J Med 2004:351;2237-2238.. Lines 11 and 12 of the letter by Rickels and Mandel should have read, “We recently diagnosed familial hypocalciuric ...