To the Editor: The Saline versus Albumin Fluid Evaluation (SAFE) Study (May 27 issue)¹ debunks a 1998 meta-analysis associating albumin with increased mortality in critical care populations.² Regrettably, this trial may spawn a new misconception: that ...

To the Editor: Lipshultz et al. (July 8 issue)¹ show that dexrazoxane reduces the cardiac toxicity of doxorubicin without compromising the antileukemic effects. Although dexrazoxane is a promising cardioprotective agent, physicians might suspect that it ...

To the Editor: Edwards et al. (June 17 issue)¹ show that the anti-CD20 monoclonal antibody rituximab provides effective therapy for rheumatoid arthritis. They report that the effects of rituximab are not associated with changes in serum immunoglobulin ...

To the Editor: Øhlenschlæger et al. (July 15 issue)¹ reported that they did not find a significant association between arterial thrombosis and the presence of antiphospholipid antibodies. However, no mention was made of whether arterial thrombosis was ...

To the Editor: In his review article on Alzheimer's disease (July 1 issue),¹ Cummings states that there is “increasing consensus” that the production of beta-amyloid (Aβ) peptide is “central to the pathogenesis of Alzheimer's disease.” He neglects to ...

To the Editor: Mathur and Grodinsky, in Images in Clinical Medicine (June 10 issue),¹ present a case in which bilateral dislocation of the intraocular lenses was examined by computed tomography (CT). We appreciate the images of this traumatic finding. ...

To the Editor: Percutaneous transluminal septal myocardial ablation is increasingly being used to treat hypertrophic cardiomyopathy. Reported complications have included atrioventricular block, extensive myocardial infarction, and death.¹,² Contrast-...

This book will go a long way toward redressing the widespread ignorance of the clinical and functional significance of the pericardium. The author, a master physiologist-cum-clinician in the mold of Louis Katz and William Dock, has produced a treasure ...

In contrast to the abundance of literature on coronary artery disease available to guide the clinician in his or her management of such disease, large-scale randomized, controlled trials are rare when it comes to valvular heart disease. Much of what is ...

Cancer is not a single genetic disease but, rather, hundreds of diseases consisting of various combinations of genetic alterations. Many types of genetic alterations contribute to neoplastic transformation. The evidence for this statement has now become ...

This extremely useful book describes the potential mechanisms underlying the macrovascular and microvascular complications of diabetes, the clinical manifestations of such abnormalities, and effective strategies for treatment. The information in its 500-...