To the Editor: Roberts and colleagues (Feb. 5 issue)¹ report that matching at the HLA-DR locus has significant effects on the survival of cadaveric renal grafts, whereas matching at the HLA-A and B loci has only small effects. They conclude that the ...

To the Editor: Boyden et al. (May 16, 2002, issue)¹ report cosegregation of a syndrome of high bone density, jaw enlargement, and torus palatinus with a missense mutation — a G-to-T substitution at position 512, encoding a glycine-to-valine substitution ...

To the Editor: The optimal duration of clopidogrel therapy after percutaneous coronary intervention is the subject of ongoing debate. Stone et al. (Jan. 15 issue)¹ report the efficacy of paclitaxel-eluting stents as compared with bare-metal stents in ...

To the Editor: The proliferation of “me-too” drugs leads to beneficial cost reductions, as Lee notes in his Perspective article (Jan. 15 issue),¹ but it may also put patients at risk. Each me-too drug comes to the market with limited clinical experience ...

To the Editor: In their editorial on antiplatelet therapy for ischemic heart disease, Lange and Hillis (Jan. 15 issue)¹ assert that in all patients who undergo percutaneous coronary intervention, clopidogrel should be added to aspirin for 9 to 12 months ...

To the Editor: In their review of acute chemical emergencies, Kales and Christiani (Feb. 19 issue)¹ mention intravenous dosages of nerve-agent antidotes, but not intramuscular autoinjectors: the MARK I kit (atropine, 2 mg, plus 2-pralidoxime chloride, ...

To the Editor: We respectfully disagree with two points in Robertson's comprehensive review of islet transplantation (Feb. 12 issue)¹: the assertions that patients with diabetes and autonomic insufficiency have a “dramatically shortened life span” and ...

To the Editor: In 2002, 51 percent of persons with tuberculosis in the United States were foreign-born; 19 percent of them had been in the United States for less than one year.¹ To prevent persons with potentially infectious tuberculosis from entering ...

Victorian euphemism had its uses. What we in our clinically literal era refer to as sexually transmitted infections once carried a more evocative label: “social diseases.” On the evidence adduced in social psychologist Catherine Campbell's remarkable book,...

Lawrence O. Gostin notes in his new book, The AIDS Pandemic, that AIDS has provoked more legislation and litigation than any other disease in modern history. As evidenced by this compilation of previously published essays, it would be equally true to say ...

This book is a collection of lectures given at a two-day symposium in 2002 with the intriguing theme “Opioids, the Janus Drugs, and the Relief of Pain.” Janus, the dual-faced Roman god, was chosen to symbolize the promise and problem that opioids ...

The Hippocratic Oath, like Handel's Messiah, is heard once a year. At medical school graduation ceremonies around the nation, 20,000 voices intone modernized, bowdlerized versions of the ancient pledge. For the rest of the year, it goes silent, except for ...