To the Editor: We have two major concerns regarding the report by Ridker et al. on low-intensity warfarin therapy (April 10 issue).¹ First, in this study, low-dose, long-term warfarin therapy resulted in a relative reduction in the risk of recurrent ...

To the Editor: Prandoni et al. (April 10 issue)¹ report the results of a case–control study suggesting an association between atherosclerosis and deep venous thrombosis. In fact, the 95 percent confidence interval for the prevalence of plaque in the ...

To the Editor: The article by Schechter and Gladwin (April 10 issue)¹ is flawed by a fundamental error. The conclusions that the authors draw from reports of measured S-nitrosohemoglobin levels and decomposition rates are not disciplined by quantitative ...

To the Editor: In their informative and practical review of the management of drug and alcohol withdrawal, Kosten and O'Connor (May 1 issue)¹ advocate the use of diazepam at a dose of 5 to 10 mg every two to four hours for the management of delirium ...

To the Editor: Paraneoplastic pemphigus has been reported in patients with Castleman's disease, and bronchiolitis obliterans in association with paraneoplastic pemphigus can eventuate in respiratory failure and death.¹–⁴ Anatomically, there is a diffuse ...

Though it might seem like the ultimate reductionist approach, the sequencing of the human genome is in fact a major advance toward achieving an integrated understanding of physiology. Contrary to the commonly used metaphor, a genome is not a ladder with ...

The aim of this new edition of The Genetic Basis of Common Diseases is to present the state of the art in the understanding of the genetics of specific illnesses. A disease is regarded as common if its prevalence is higher than 1 in 1000. The etiology of ...

This collection of essays focuses on all aspects of the emerging field of pharmacogenomics except the science that underpins it. This omission is understandable because the science of pharmacogenomics is currently clouded by uncertainty. Pharmacogenomics ...

The quantitative analysis of the heritability of mental disorders, together with the demonstration of specific neuronal actions of psychotropic drugs, changed the conception of mental illness from a personal and family disgrace to a disorder of brain ...

Hodgkin's Disease — Clinical Trials and Travails Perspective, N Engl J Med 2003:348;2375-2376.. On page 2375, the epigraph should have been attributed to Louis Pasteur, rather than to René J. Dubos, as printed.

A 20-Hour Treatment for Acute Acetaminophen Overdose Correspondence, N Engl J Med 2003:348;2471-2472.. On page 2472, lines 11 and 12 of the left-hand column should have read “48 hours after the administration of the N-acetylcysteine loading dose,” rather ...