To the Editor: In the study by Kearon et al. (Aug. 14 issue),¹ which compared low-intensity warfarin with conventional-intensity warfarin for long-term prevention of recurrent venous thromboembolism, conventional-intensity therapy (target international ...

To the Editor: Trials have shown that thrombolysis, as compared with placebo, reduces mortality even though it is associated with increases in the rates of reinfarction and stroke.¹,² The Danish Multicenter Randomized Study on Fibrinolytic Therapy versus ...

To the Editor: In their letter to the editor, Ferranti and Menichetti (Aug. 21 issue)¹ propose that enfuvirtide “should be considered for prophylaxis against HIV-1 [human immunodeficiency virus type 1] infection in cases of high-risk exposure to a ...

To the Editor: In their editorial (Sept. 4 issue),¹ Guttmacher and Collins provide a conventional and optimistic overview of the effects of genomics on clinical practice. Absent from their discussion is mention of the most common current use of genetics ...

To the Editor: In Case 27-2003 (Aug. 28 issue),¹ a patient with two rare diseases — lymphoplasmacytic sclerosing pancreatitis and amyotrophic lateral sclerosis — is described. The pathological discussion concludes with the statement that these two ...

To the Editor: Determination of pregnancy status is vital in the workup of a patient presenting with vaginal bleeding or lower abdominal pain. We report a case of false negative results on urine and serum pregnancy tests as a result of the “high-dose ...

To the Editor: Cystic lesions of the spleen are rare findings. We describe a patient with a very large epithelial splenic cyst. A 32-year-old woman presented to our clinic with a several-month history of abdominal pain and a sensation of fullness in her ...

What has been the impact of medical care on health over time? To answer that long-standing and still troubling question, Chris Feudtner has given us a term to use: bittersweet. Examining the history of insulin therapy, Feudtner describes what he calls the ...

Since its publication in 1987, Lauri Saxén's superb monograph Organogenesis of the Kidney (Cambridge, United Kingdom: Cambridge University Press) has been the benchmark by which other books in the field have been judged. The past 15 years have witnessed ...

Nicholas tilney has written an enjoyable book about the history of organ transplantation, suitable for both professionals and laypersons alike. There is limited medical jargon to interfere with reading by a general audience, yet sufficient technical ...