Issue IndexA searchable index of tables of contents
Find An Issue
Table of contents for
July 10, 2003 Vol. 349 No. 2
- Free Full Text
Most kidney transplants fail because of chronic allograft nephropathy or the death of the recipient, but methods for predicting such an outcome have been lacking. This study evaluated the predictive value of the renal segmental arterial resistance index (the percentage reduction of the end-diastolic flow as compared with the systolic flow). A high resistance index (80 or higher) was associated with an increased risk of a reduction in creatinine clearance, allograft failure, or death.
- Free Full Text
In this study, DNA microarrays were used to examine gene-expression patterns in biopsy samples from normal and dysfunctional renal allografts. Subtypes of acute rejection, indistinguishable by light microscopy, could be distinguished by differences in immune activation and cellular proliferation. Dense CD20+ B-cell infiltrates were significantly associated with clinical glucocorticoid resistance and graft loss.
- Free Full Text
In this study of 103 patients with new neurologic symptoms, abnormalities on MRI, and cerebrospinal fluid findings that suggested multiple sclerosis, patients with antibodies to myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) were much more likely to have recurrent symptoms and progression to clinically definite multiple sclerosis than those without these antibodies.
- Free Full Text
Secondary prophylaxis against recurrent deep-vein thrombosis is important in patients with cancer, since these patients have an increased risk of recurrence. The researchers compared dalteparin, a low-molecular-weight heparin, with an oral anticoagulant drug for six months after the initial event and found fewer recurrences with heparin.
Giant-cell arteritis typically involves extracranial branches of the aorta, such as the temporal and vertebral arteries. Temporal arteritis and polymyalgia rheumatica often coexist, and systemic manifestations of inflammation occur in virtually all forms of giant-cell arteritis. This article reviews the mechanisms that contribute to the causes of giant-cell arteritis, with an emphasis on immune-mediated injury to arteries.
Molecular mimicry is a model in which foreign antigens are sufficiently similar to native antigens to trigger an autoimmune response. A study involving the specificity of a T-cell receptor derived from a patient with multiple sclerosis indicates that molecular mimicry extends to complexes of proteins — a finding with implications for therapy.
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text





