To the Editor: The conclusion drawn by Rodenhuis et al. (July 3 issue)¹ — that high-dose therapy improves relapse-free survival among patients with 10 or more positive nodes — is untenable. The authors failed to apply the method specified in their ...

To the Editor: Regarding the article by Selzer et al. on the adverse effect of nitrous oxide (July 3 issue),¹ I would like to point out that, in 1978, my colleagues and I showed that nitrous oxide inactivated vitamin B₁₂ in vivo.² My colleague John Amess,...

To the Editor: Rosenthal (July 17 issue)¹ begins her article by considering the myth of Prometheus. She says that a vulture preyed daily on his self-renewing liver. Indeed, Greek mythology tells us that a bird ate Prometheus's liver, but older sources ...

To the Editor: Regarding your editorial in the July 17 issue,¹ I would like to extend my compliments and appreciation to you and your editorial staff for making the publication of stem-cell research a priority. My mother has been fighting Parkinson's ...

To the Editor: Case 11-2003 (April 10 issue)¹ describes a 14-year-old boy with recurrent cholangitis complicating ulcerative colitis. The authors state that this presentation is unusual in such a young patient. We report a similar experience of a ...

To the Editor: The Case Records on the 72-year-old man with giant-cell arteritis (July 10 issue)¹ include a comment from a house officer: “As one of the house officers caring for this patient, I developed a relationship with him and his family. Probably ...

To the Editor: Reliable assessment of molecular remission after allografting for chronic myeloid leukemia requires assays capable of detecting one BCR-ABL–positive cell among 10⁵ to 10⁶ BCR-ABL–negative cells¹ — a sensitivity achieved with nested reverse-...

The death of a child holds such sadness for many health care professionals that they will have trouble bringing themselves to read a book that so openly considers this tragedy. Yet it is critical that those same professionals delve into this book. Within ...

This book contains a wealth of information to assist physicians with the care of children who are in pain. The book has three sections, covering theoretical perspectives, treatment strategies, and particular problems. The first section deals with the ...

Along with the many infirmities of old age, pain is a common occurrence. The causes of pain in the elderly, unlike those that affect younger adults, are often complex and not likely to be reversible. The physical discomfort of pain is only one facet of ...

Insulin Lispro Review Article, N Engl J Med 1997:337;176-183.. In Figure 2 on page 177, the last amino acid at the C-terminal end of the sequences for insulin lispro and human insulin should have been “Thr,” rather than “Tyr,” as printed.

Tissue Plasminogen Activator in Cardiac Arrest with Pulseless Electrical Activity Original Article, N Engl J Med 2002:346;1522-1528.. In Table 3 on page 1524, the numbers and percentages of patients who received atropine should have been 108 (92.3) in the ...