Issue IndexA searchable index of tables of contents
Find An Issue
Table of contents for
February 6, 2003 Vol. 348 No. 6
High-risk patients undergoing angiography are susceptible to nephrotoxic effects. This randomized, double-blind, prospective study evaluated the frequency of nephropathy in patients with diabetes and base-line serum creatinine concentrations of 1.5 to 3.5 mg per deciliter. They received either the iso-osmolar, dimeric, nonionic contrast medium iodixanol or the low-osmolar, nonionic, monomeric contrast medium iohexol. The increase in creatinine and the rate of frank nephropathy were significantly lower among those who received the iso-osmolar agent.
Proliferation of smooth-muscle cells in pulmonary arterioles is central to the pathogenesis of pulmonary hypertension. In this study, a signaling pathway involved in smooth-muscle proliferation was found to be altered in patients with nonfamilial forms of pulmonary hypertension. The pathway includes angiopoietin-1, a molecule that signals the recruitment of smooth-muscle cells, its receptor TIE2, and bone morphogenetic protein receptor type 2.
- Free Full Text
Three hundred two patients with cocaine-associated chest pain who were at low to intermediate risk were discharged from a chest-pain observation unit after 9 to 12 hours of observation and were followed for 30 days. There were no deaths from cardiovascular causes and only four nonfatal myocardial infarctions (all four in patients who continued to use cocaine). In contrast, an acute coronary syndrome was diagnosed in 20 of 42 high-risk patients who were directly admitted to the hospital (and thus not included in the study).
- Free Full Text
The type of human papillomavirus (HPV) in exfoliated cervical cells from almost 2000 women with cervical cancer and a similar number of control women from nine countries was determined by the polymerase chain reaction in 11 studies. Of the 33 types of HPV that were assayed, 18 were classified as high-risk or probable high-risk types and 12 as low-risk types. Odds ratios for cervical cancer that exceeded 200 were associated with HPV 16, 59, 33, and 18.
- Free Full Text
- Video
There is substantial variability among individual patients in the responses to pharmaceutical agents. Among the sources of variation in response are genetic differences in the enzymes responsible for drug metabolism, differences in the targets of the drug, and differences in genes that lead to side effects. Two articles in this issue — a Genomic Medicine article and a Drug Therapy review — discuss a number of clinically relevant inherited variants that affect drug action or side effects; the study of such variants forms the basis of the field of pharmacogenetics.
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text
- Free Full Text






