To the Editor: The use of systemic corticosteroids in patients with the severe acute respiratory syndrome (SARS) is of serious concern. Lee and colleagues report anecdotal success in their article on SARS elsewhere in this issue.¹ And in the recent Web ...

To the Editor: The outbreak of a new, potentially severe, infectious disease, without known cause or treatment, is a stressful challenge, both for patients and for physicians. Our only therapeutic weapons may be individual protection by means of masks, ...

To the Editor: The study by Sandham et al. (Jan. 2 issue)¹ showed no improvement in outcome resulting from goal-directed therapy guided by pulmonary-artery catheter in high-risk surgical patients. The main targets (an oxygen-delivery index of 550 to 600 ...

To the Editor: The article by Yáñez-Mó et al. (Jan. 30 issue)¹ is timely, since there have been many recent reports showing similar epithelial-to-mesenchymal transitions in inflammatory and malignant processes.² We would, however, like to address several ...

To the Editor: Kirschke et al. and Srinivasan et al. (Jan. 16 issue)¹,² report contamination associated with a defect in bronchoscopes in the United States. A similar event occurred in Lyons, France, during the same period. From March 5, 2001, to October ...

To the Editor: Muñoz et al. (Feb. 6 issue)¹ classified human papillomavirus (HPV) types 81 and 73 as low-risk and high-risk HPV types, respectively, on the basis of their relative frequency in cervical cancer. This is in agreement with our previous ...

To the Editor: The review by Weinshilboum on the inheritance of drug response (Feb. 6 issue)¹ focuses on the pharmacogenetics of drug metabolism as an important factor in the variability of drug effects among persons. An aspect of this topic that is not ...

To the Editor: Gnann and Whitley (Aug. 1 issue)¹ state that serologic testing for the human immunodeficiency virus (HIV) may be appropriate for healthy persons with herpes zoster who are younger than 50 years of age. Herpes zoster develops in more than ...

To the Editor: We recently encountered two patients with Waldenström's macroglobulinemia¹ who had a marked increase in the serum concentration of IgM M component during treatment with cladribine.² Patient 1, a 78-year-old woman, reported shortness of ...

As the field of cancer epidemiology becomes increasingly broad and complex, studies are being conducted to examine how environmental exposure, lifestyle choices, and genetic susceptibilities influence the risk of cancer. It is not easy to keep abreast of ...

Every year, approximately 3500 children are given a diagnosis of acute leukemia, as compared with about 11,000 adults. Thus, one might expect that in a book devoted to the treatment of the acute leukemias, most of the chapters would discuss acute leukemia ...

Over the course of the past two decades, dramatic gains in knowledge have led directly to improvements in the early diagnosis of prostate cancer and to more effective treatment with fewer adverse effects. Even so, prostate cancer continues to kill tens of ...

Management of Urologic Malignancies focuses on a simplified approach to treating patients with cancers of the genitourinary tract. The goal, as stated in the preface, is for the book to serve as a reference source for the clinician, regardless of whether ...

Shattuck Lecture — Diversity of the Immune Repertoire and Immunoregulation Special Article, N Engl J Med 2003:348;1017-1026.. On page 1023, in Table 1, sirolimus and its principal mode of action should not have been included. On page 1024, in Figure 5, ...