To the Editor: In their article comparing prostatectomy with watchful waiting, Holmberg et al. (Sept. 12 issue)¹ present their analysis according to the intention-to-treat principle, but the true treatment effect might be larger than that observed ...

To the Editor: Investigators in the Allergy and Endotoxin (ALEX) Study have shown previously that exposure to stables and farm milk during the first year of life protects against asthma and hay fever at 6 to 13 years of age, plausibly through exposure to ...

To the Editor: Boyd et al. (Sept. 19 issue)¹ estimated that the heritability of mammographic density was 60 percent among Australian twins and 67 percent among American twins. Although twin studies reveal little about the mode of inheritance, we ...

To the Editor: Martyny et al. (Sept. 12 issue)¹ provide a very useful review of respiratory protection; however, a few points should be noted. Some self-contained breathing apparatuses, such as rebreathers, can last several hours. The note that air-...

To the Editor: There was no mention of human immune globulin therapy in the discussion of the patient who died from group A streptococcal toxic shock syndrome and necrotizing fasciitis (Case 28-2002) (Sept. 12 issue).¹ Yet timely immune globulin therapy ...

To the Editor: Mutations in the YMDD (tyrosine, methionine, aspartate, aspartate) motif of the DNA polymerase resulting in phenotypic hepatitis B virus (HBV) resistance to lamivudine monotherapy have been observed after two years in 50 percent of ...

To the Editor: The role of hepatitis C virus (HCV) and human herpesvirus 8 (HHV-8), two B-cell–tropic viruses, in B-cell proliferation¹ is illustrated by the following unusual case of plasma-cell leukemia. In 1995, a 32-year-old man with a history of ...

On the first page of this big book, the editors tell us that “there have been major advances in the understanding of motor and non-motor operations of the cerebellum.” But one must read between the lines of this and other books that summarize our ...

The trajectory of discovery in science and medicine is rarely linear. On the contrary, it is nearly always erratic, with peaks of insight, troughs of wrong hypotheses, midcourse corrections, and ultimate enlightenment. In this profusely illustrated coffee-...

In 1987, William F. Brown and Charles F. Bolton wrote the first edition of their now classic textbook, Clinical Electromyography, which was substantially expanded in 1993 on the basis of increased knowledge of neuromuscular diseases. The book is one of ...

Availability of Neonatal Intensive Care and Neonatal Mortality Correspondence, N Engl J Med 2002:347;1893-1895.. In some copies of the Journal, the first sentence of the editorialist's reply on page 1895 was obscured. The sentence should have read “The ...

Cyclin E and Survival in Patients with Breast Cancer Original Article, N Engl J Med 2002:347;1566-1575.. On page 1572, the curves in Figure 3C were incorrect. The corrected Panel C appears below.