To the Editor: Lin et al. (Jan. 23 issue)¹ implicate lead exposure in the progression of renal disease on the basis of the effect of EDTA chelation. However, there are compelling experimental data implicating iron (mobilized from endogenous sources and ...

To the Editor: Hoberman et al. (Jan. 16 issue)¹ attribute the small effect of renal ultrasonography in the clinical management of febrile urinary tract infections to the widespread use of prenatal ultrasonography. However, reports and images from ...

To the Editor: Zhang et al. (Jan. 16 issue)¹ report that the presence of intratumoral T cells, detected by immunohistochemical analysis, correlates with an improved clinical outcome in patients with advanced ovarian carcinoma. However, it is not clear ...

To the Editor: In the article by Maron et al. (Jan. 23 issue)¹ about the effect of left ventricular outflow tract obstruction on the clinical outcome in hypertrophic cardiomyopathy, the authors conclude that patients with obstructive hypertrophic ...

To the Editor: Tinetti (Jan. 2 issue)¹ discusses the benefit of targeted interventions in reducing the occurrence of falls in elderly persons. We believe vitamin D status deserves greater emphasis. Myopathy associated with vitamin D insufficiency ...

To the Editor: In their interesting review article on regional analgesia for labor and delivery, Eltzschig et al. (Jan. 23 issue)¹ state that the decision to receive any form of analgesia is personal and should be made by the patient in consultation with ...

To the Editor: Vesicoenteric fistula usually develops as a complication of colonic diverticulitis, although other conditions, such as colorectal cancer, Crohn's disease, and bladder cancer, may be associated with it. Urinary symptoms such as pneumaturia ...

To the Editor: Thalidomide is used to treat multiple myeloma because of its apoptotic¹ and antiangiogenic² properties. Common side effects of thalidomide in patients with multiple myeloma include sedation and peripheral neuropathy.³ We describe a case of ...

The death of Roy Porter at the age of 55 years in early 2002 was a grievous loss for both the scholarly community and the general public. One of the most prolific historians of his generation, Porter wrote and edited about 80 books. In a world of ...

This is a gripping insider's story of the Human Genome Project, revealing both the exciting science leading to it and the battle to keep the results, “the heritage of humanity,” secure from control by private interests. As the authors state in the preface,...

The Double-Edged Helix takes a cautious look at the effects of genetic discoveries on society. It warns that neither society nor genetics is governed by simple cause-and-effect mechanisms and that this complexity creates potential for both benefit and ...