To the Editor: The study by van de Vijver et al. (Dec. 19 issue)¹ is of considerable interest with respect to the biology of breast cancer. However, from the point of view of the individual patient and her physician, the sensitivity and specificity of ...

To the Editor: Keller et al. (Jan. 9 issue)¹ report that patients with hypertension have fewer nephrons than do age-matched normotensive controls. Is hypertension therefore predetermined by a low nephron number, and, if so, how does this occur? Reduction ...

To the Editor: Mukamal et al. (Jan. 9 issue)¹ report on the roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. Although alcohol consumption reduces mortality from coronary heart disease, it has not been shown to have ...

To the Editor: The concept that phenylketonuria may be cured by tetrahydrobiopterin, the cofactor of phenylalanine hydroxylase, rather than by dietary protein restriction, has generated a number of therapeutic attempts. Muntau et al. (Dec. 26 issue)¹ ...

To the Editor: In explaining the association between increased body-mass index and a higher risk of retention of a surgical instrument or sponge, Gawande et al. (Jan. 16 issue)¹ suggest that the increased risk may reflect “the amount of room there is in ...

To the Editor: Shevell's scholarly and articulate review of the Hallervorden–Spatz syndrome (Jan. 2 issue)¹ is to be applauded, but he should reconsider the contention that Hallervorden's eponym should be discarded because of his ethical transgressions ...

To the Editor: First described in 1968, pacemaker twiddler's syndrome refers to permanent malfunction of a pacemaker due to the patient's manipulation of the pulse generator.¹ The sequence of symptoms begins with the patient's deliberate or subconscious ...

Fifty years ago, a young South African student who was destined to win the Nobel prize made the short pilgrimage from Oxford to Cambridge to pay his respects to a chemical model on display in Room 103 of the Cavendish Laboratory. It was, Sydney Brenner ...

This biography illuminates one of the most mysterious protagonists in a fascinating story of fibers, photographs, and feelings, in which biology is revolutionized with the discovery of the double-helix structure of DNA. Rosalind Franklin, Maddox's “dark ...

Magnesium Sulfate for Preeclampsia Perspective, N Engl J Med 2003:348;275-276.. On page 276, the figure legend should have read “Autopsy Specimen from a 40-Year-Old Woman with Severe Preeclampsia and Acute Intraparenchymal and Intraventricular Hemorrhage” ...