To the Editor: Yamada et al. (Dec. 12 issue)¹ state that the identification of genotypes of the 4G–668/5G polymorphism of the gene encoding plasminogen-activator inhibitor type 1 may be a reliable means of predicting the risk of myocardial infarction in ...

To the Editor: Hulscher and colleagues' success with transhiatal and transthoracic surgical approaches for esophageal carcinoma (median survival, 1.8 and 2.0 years, respectively) explains why they found no difference between the two procedures (Nov. 21 ...

To the Editor: Bockarie et al. (Dec. 5 issue)¹ provide encouraging new evidence that mass treatment with antifilarial drugs can interrupt transmission of Wuchereria bancrofti. However, their conclusion that this strategy can eliminate filarial lymphedema ...

To the Editor: In the studies of high-frequency ventilation reported in the August 29 issue by Johnson et al.¹ and Courtney et al.,² there were important differences in the application of conventional ventilation in the control groups, which may explain ...

To the Editor: In their review article about typhoid fever, Parry et al. (Nov. 28 issue)¹ describe the clinical features of infection with Salmonella enterica serotype typhi but do not mention renal failure as an important complication. We have reviewed ...

To the Editor: Physicians underestimate the degree to which medical care, which was formerly simple, ineffective, and safe, is now complex, effective, and unsafe. Blendon et al. (Dec. 12 issue)¹ report that physicians are aware of medical errors but ...

To the Editor: We read with concern the analysis by Davidson et al. (Sept. 26 issue).¹ They use the pooled placebo groups from two sepsis trials, divided into two groups — patients who either were receiving heparin at the time they entered the trial or ...

To the Editor: Fabry's disease is a rare, X-linked disorder characterized by subnormal or absent activity of the lysosomal hydrolase α-galactosidase A. A deficiency of α-galactosidase A leads to progressive lysosomal accumulation of glycosphingolipids (...

To the Editor: Bisphosphonates are used to inhibit bone resorption in postmenopausal women and to manage hypercalcemia associated with osteolytic bone cancer, metastases of breast cancer, multiple myeloma, and Paget's disease of bone. Pamidronate ...

Margaret Spinelli has gathered a group of experts to examine the subject of maternal infanticide from biologic, psychosocial, legal, and cultural perspectives. Her book handles the material sensitively, with an eye toward prevention. It also serves as a ...

The “shaken-baby syndrome” is a serious public health problem that escaped the radar of the medical, legal, and larger community for far too long. Silenced Angels sends the message that this syndrome is a completely identifiable and preventable public ...

This interesting collection of historical essays was presented at the University of Michigan in September 2000 at a symposium named for the first professor of pediatrics, David Murray Cowie. It is not intended to be a comprehensive history of pediatrics ...

Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Negative Chronic Hepatitis B Original Article, N Engl J Med 2003:348;800-807. and Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Positive Chronic Hepatitis B Original Article, N ...

Selective Estrogen-Receptor Modulators — Mechanisms of Action and Application to Clinical Practice Review Article, N Engl J Med 2003:348;618-629.. There was an error in Figure 2; a corrected figure is shown here.