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March 6, 2003 Vol. 348 No. 10
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In this randomized, double-blind trial, daily ingestion of aspirin reduced the incidence of colorectal polyps among patients with previous colorectal cancer. Of 258 patients in the placebo group who underwent colonoscopy, polyps were found in 70, whereas 43 of 259 patients in the aspirin group were found to have polyps.
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Among more than 15,000 women in a community-based cohort, both cesarean section and vaginal delivery were associated with increased risk of urinary incontinence later in life. Furthermore, moderate or severe incontinence was more than twice as likely after vaginal delivery as after cesarean section, after adjustment for age and other potential confounders.
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Treatment with a luteinizing hormone–releasing hormone (LHRH) agonist increases adult height in children with precocious puberty. This study was designed to determine whether LHRH-agonist therapy would increase adult height in short adolescents with normally timed puberty. The adolescents had an increase of 0.6 in the standard-deviation score for height, as compared with the initially predicted adult height; however, bone mineral density was decreased.
Colorectal cancers among patients with a familial risk of this disorder account for approximately one of five cases of this disease. Many cases can be prevented by the identification of those at risk and the use of appropriate colonoscopic screening. This article, part of the Genomic Medicine series, provides an in-depth review of the two most common forms of familial colorectal cancer.
This review article describes the use of electrocardiograms in facilitating the clinical care of patients with acute myocardial infarction. Analysis of patterns of ST-segment elevation can help in making decisions about reperfusion therapy. Correct identification of arrhythmias and new conduction abnormalities is an important challenge.
Some women would prefer an elective cesarean delivery to labor. The authors of this Sounding Board article review the arguments for and against elective cesarean delivery. They conclude that the available data do not support the routine recommendation of this approach but that they do support a physician's acceding to a request for cesarean delivery made by an informed patient.
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