To the Editor: In this issue of the Journal, Warren et al.¹ and Siegel² offer their views on the approval of drotrecogin alfa (activated), or recombinant human activated protein C, for the treatment of severe sepsis. We concur with Dr. Siegel's comments ...

To the Editor: In their report on the efficacy of activated protein C in reducing mortality from sepsis at 28 days (March 8, 2001, issue),¹ Bernard et al. presented the results of a retrospective subgroup analysis, which showed that the administration of ...

To the Editor: Kauff et al. (May 23 issue)¹ present data suggesting that salpingo-oophorectomy provides protection against breast or gynecologic cancer in women with a BRCA1 or BRCA2 mutation. Although the follow-up period was relatively short and ...

To the Editor: Brightling et al. (May 30 issue)¹ report that, in patients with asthma, there is mast-cell infiltration of airway smooth muscle associated with hyperresponsiveness. As pointed out by the authors and by Black in an accompanying editorial,² ...

To the Editor: According to Ganzini and Block (May 23 issue),¹ “experts assert that with excellent palliative care, most requests for hastened death would not be made.” They consider rates of physician-assisted death of 10 to 20 percent, as reported for ...

To the Editor: In 1990, I proposed the Journal's stringent policy for authors of review articles and editorials¹ because I thought it was the best way to preserve our readers' confidence in the objectivity of those articles. The recent extraordinary ...

To the Editor: The report by Ostrowsky et al. (May 16 issue)¹ and the Perspective by Verghese² highlight the importance of impairment due to alcohol and drug dependence among physicians and other health care workers. Addiction spares no race or class in ...

Like motorists who slow down to stare at the aftermath of car crashes, most people are fascinated by meteorologic disasters. The perils of weathering a hurricane, a tsunami's destruction of property, and the human drama of a flood all make for riveting ...

Sexual assault has become a complicated issue over the past decade and poses many difficulties in prevention and diagnosis. With the availability of disabling drugs such as “ecstasy,” the phrase “slipped a Mickey Finn” has taken on new meaning, not only ...

How does a modern journalist tell a story subtitled The Rise and Fall of America's Premier Mental Hospital? A book about McLean Hospital, an institution that for nearly 200 years treated mentally ill members of Boston's social and intellectual elite, ...

An extensive body of empirical research, which has grown dramatically over the past 10 years, has documented the profoundly important influence of body image on the quality of life. The editors of this book have made an important and timely contribution ...

Photo filler (August 8, 2002;347:400). The photograph printed on page 400 should have been credited to Robert B. Cubberley, M.D., rather than Glenn Zachow, M.D. We regret the error.

Seizure Associated with the Use of Visicol for Colonoscopy Correspondence, N Engl J Med 2002:346;2095.. On page 2095, the last name of the third author of the letter should have been "Prizont" rather than "Prizant." We regret the error.