Concern about mosquitoes, ticks, and the pathogens that they transmit grows annually in temperate parts of the world with the leafing of the trees. The arrival of West Nile virus in North America in 1999 has added to anxieties about arthropods (see Figure)...

It is uncertain whether thrombophilia polymorphisms in women are associated with an increased risk of intrauterine growth restriction in their offspring. In this large case–control study, the presence in the mother or newborn of polymorphisms for methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C, factor V Leiden G1691A, or prothrombin G20210A was not associated with an increased risk of intrauterine growth restriction (defined as birth weight below the 10th percentile).

The realization that atherosclerosis is, morphologically, an inflammatory disease was originally derived from studies of animal models. Early after the initiation of an atherogenic diet in animals, monocytes adhere to the vascular endothelium and ...

To the Editor: The results of two studies reported in the Journal (Feb. 21 issue)¹,² suggest that therapeutic hypothermia has a beneficial effect on neurologic outcome in survivors of out-of-hospital cardiac arrest. The authors of the accompanying ...

To the Editor: Davidson et al. (March 7 issue)¹ describe four patients with pneumococcal pneumonia in whom therapy with oral levofloxacin failed. We report on a patient with pneumococcal pneumonia and bacteremia in whom meningitis and sepsis developed ...

To the Editor: Savage and Antman (Feb. 28 issue)¹ summarize the pathogenesis of BCR-ABL–positive chronic-phase leukemias that are responsive to imatinib mesylate therapy. The authors point out that the mechanism of the antiproliferative action of ...

To the Editor: Dr. Schmidt (Feb. 21 issue)¹ appears not to appreciate the powerful need people have to give blood when a tragedy strikes or the potent symbolism involved. When America's Blood Centers, whose community-based network provides nearly half of ...

To the Editor: Pulmonary alveolar microlithiasis is a rare disease of unknown pathogenesis, characterized by widespread laminated calcispherites in alveolar spaces in the absence of any known disorder of calcium metabolism.¹ It usually occurs in a ...

It is an exciting time to be a practitioner in the field of colon and rectal neoplasia. The past decade has brought great progress in our understanding of the environmental and genetic basis of this disease and in our ability to treat it successfully. ...

In a 1987 editorial accompanying two reports on the use of interleukin-2 for treating advanced cancer, John Durant, after several calls for caution, concluded that perhaps we were at the end of the beginning of the search for successful immunotherapy for ...